Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo-Dimeric Sensor Protein

Bifunctional enzymes, which contain two domains with opposing enzymatic activities, are widely distributed in bacteria, but the regulatory mechanism(s) that prevent futile cycling are still poorly understood. The recently described bifunctional enzyme, DcpG, exhibits unusual heme properties and is s...

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Veröffentlicht in:	Biochemistry (Easton) 2021-12, Vol.60 (49), p.3801-3812
Hauptverfasser:	Patterson, Dayna C, Liu, Yilin, Das, Sayan, Yennawar, Neela H, Armache, Jean-Paul, Kincaid, James R, Weinert, Emily E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Cyclic GMP - analogs & derivatives Cyclic GMP - chemistry Cyclic GMP - metabolism Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Heme - chemistry Heme - metabolism Hemeproteins - chemistry Hemeproteins - genetics Hemeproteins - metabolism Kinetics Models, Molecular Oxygen - chemistry Oxygen - metabolism Paenibacillus - chemistry Paenibacillus - enzymology Paenibacillus - genetics Phosphoric Diester Hydrolases - chemistry Phosphoric Diester Hydrolases - genetics Phosphoric Diester Hydrolases - metabolism Phosphorus-Oxygen Lyases - chemistry Phosphorus-Oxygen Lyases - genetics Phosphorus-Oxygen Lyases - metabolism Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Static Electricity Structure-Activity Relationship Substrate Specificity
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