Structure and Mechanism of the Ketosynthase-Chain Length Factor Didomain from a Prototypical Polyunsaturated Fatty Acid Synthase

Long-chain polyunsaturated fatty acids (LC-PUFAs) are essential ingredients of the human diet. They are synthesized by LC-PUFA synthases (PFASs) expressed in marine bacteria and other organisms. PFASs are large enzyme complexes that are homologous to mammalian fatty acid synthases and microbial poly...

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Veröffentlicht in:	Biochemistry (Easton) 2020-12, Vol.59 (50), p.4735-4743
Hauptverfasser:	Santín, Omar, Yuet, Kai, Khosla, Chaitan, Moncalián, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Biosynthetic Pathways Catalytic Domain - genetics Crystallography, X-Ray Fatty Acid Synthase, Type II - chemistry Fatty Acid Synthase, Type II - genetics Fatty Acid Synthase, Type II - metabolism Fatty Acids, Unsaturated - biosynthesis Fatty Acids, Unsaturated - chemistry Humans Mass Spectrometry Models, Molecular Moritella - enzymology Moritella - genetics Mutagenesis, Site-Directed Protein Domains Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid Static Electricity Substrate Specificity
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