Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5‑Methylcytosine in the CGG Repeat

The methylation of cytosine in the full mutation of the expanded CGG repeat and subsequent deamination to thymine could be a measure of repeat instability. We report the synthesis of NCD-Bpy, which binds to the TGG/CGG site in the repeat hairpin. NCD-Bpy forces the thymine in the TGG/CGG site to fli...

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Veröffentlicht in:	Biochemistry (Easton) 2020-07, Vol.59 (29), p.2679-2683
Hauptverfasser:	Yagi, Yuki, Yamada, Takeshi, Nakatani, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - chemical synthesis 2,2'-Dipyridyl - chemistry 5-Methylcytosine - analysis Deamination Methylation Naphthyridines - chemical synthesis Naphthyridines - chemistry Thymine - analysis Trinucleotide Repeat Expansion Trinucleotide Repeats
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