Auditory brainstem evoked potentials in asymptomatic lead-exposed subjects
Auditory Brainstem Evoked Potentials (ABEP) were recorded from 29 adults and children, accidentally exposed to lead through food until approximately a year prior to this study. ABEP were recorded in response to 75 dBHL click presented at rates of 10/sec. and 55/sec. Average values were calculated fo...
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Veröffentlicht in: | Journal of laryngology and otology 1986-09, Vol.100 (9), p.1031-1036 |
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container_title | Journal of laryngology and otology |
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creator | Holdstein, Y. Pratt, H. Goldsher, M. Rosen, G. Shenhav, R. Linn, S. Mor, A. Barkai, A. |
description | Auditory Brainstem Evoked Potentials (ABEP) were recorded from 29 adults and children, accidentally exposed to lead through food until approximately a year prior to this study. ABEP were recorded in response to 75 dBHL click presented at rates of 10/sec. and 55/sec. Average values were calculated for peak latency and for interpeak latency differences. Average values of the effect of increasing stimulus rate were calculated as well. Similar values were calculated for normative child and adult control groups. IPLD (I-III) showed the most significant and recurring results, with longer intervals in lead-exposed children compared with their control group. Increasing stimulus rate, on the other hand, affected the adult lead-exposed subjects more than the children. These results may imply an impairment of the auditory system with azonal and myelin involvement. ABEP is suggested as a sensitive detector of subclinical lead exposure effects on the nervous system. |
doi_str_mv | 10.1017/S0022215100100519 |
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ABEP were recorded in response to 75 dBHL click presented at rates of 10/sec. and 55/sec. Average values were calculated for peak latency and for interpeak latency differences. Average values of the effect of increasing stimulus rate were calculated as well. Similar values were calculated for normative child and adult control groups. IPLD (I-III) showed the most significant and recurring results, with longer intervals in lead-exposed children compared with their control group. Increasing stimulus rate, on the other hand, affected the adult lead-exposed subjects more than the children. These results may imply an impairment of the auditory system with azonal and myelin involvement. ABEP is suggested as a sensitive detector of subclinical lead exposure effects on the nervous system.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S0022215100100519</identifier><identifier>PMID: 3760684</identifier><identifier>CODEN: JLOTAX</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Brain Stem - physiopathology ; Chemical and industrial products toxicology. Toxic occupational diseases ; Child ; Evoked Potentials, Auditory - drug effects ; Female ; Humans ; Lead Poisoning - diagnosis ; Lead Poisoning - physiopathology ; Male ; Medical sciences ; Metals and various inorganic compounds ; Middle Aged ; Time Factors ; Toxicology</subject><ispartof>Journal of laryngology and otology, 1986-09, Vol.100 (9), p.1031-1036</ispartof><rights>Copyright © JLO (1984) Limited 1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-b3eeca4b95693839488c3d592b5e5a4813090cf03bb8f8e7f8d52147e7a8f55c3</citedby><cites>FETCH-LOGICAL-c322t-b3eeca4b95693839488c3d592b5e5a4813090cf03bb8f8e7f8d52147e7a8f55c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022215100100519/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27903,27904,55607</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7979965$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3760684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holdstein, Y.</creatorcontrib><creatorcontrib>Pratt, H.</creatorcontrib><creatorcontrib>Goldsher, M.</creatorcontrib><creatorcontrib>Rosen, G.</creatorcontrib><creatorcontrib>Shenhav, R.</creatorcontrib><creatorcontrib>Linn, S.</creatorcontrib><creatorcontrib>Mor, A.</creatorcontrib><creatorcontrib>Barkai, A.</creatorcontrib><title>Auditory brainstem evoked potentials in asymptomatic lead-exposed subjects</title><title>Journal of laryngology and otology</title><addtitle>J. Laryngol. Otol</addtitle><description>Auditory Brainstem Evoked Potentials (ABEP) were recorded from 29 adults and children, accidentally exposed to lead through food until approximately a year prior to this study. ABEP were recorded in response to 75 dBHL click presented at rates of 10/sec. and 55/sec. Average values were calculated for peak latency and for interpeak latency differences. Average values of the effect of increasing stimulus rate were calculated as well. Similar values were calculated for normative child and adult control groups. IPLD (I-III) showed the most significant and recurring results, with longer intervals in lead-exposed children compared with their control group. Increasing stimulus rate, on the other hand, affected the adult lead-exposed subjects more than the children. These results may imply an impairment of the auditory system with azonal and myelin involvement. ABEP is suggested as a sensitive detector of subclinical lead exposure effects on the nervous system.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain Stem - physiopathology</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Child</subject><subject>Evoked Potentials, Auditory - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Lead Poisoning - diagnosis</subject><subject>Lead Poisoning - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Middle Aged</subject><subject>Time Factors</subject><subject>Toxicology</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEURYMotVZ_gAthFm5H8zGZJMtatFUEKypdhiSTkbSdD5IZaf-9KS3dCMKDt7jnPh4HgGsE7xBE7P4DQowxogjCOBSJEzBELOMpzXJ4Coa7ON3l5-AihCWMGIN4AAaE5TDn2RC8jPvCdY3fJtorV4fOVon9aVa2SNqms3Xn1Dokrk5U2FZt11SqcyZZW1WkdtM2IXKh10trunAJzsoI26vDHoGvp8fPySx9fZs-T8avqSEYd6km1hqVaUFzQTgRGeeGFFRgTS1VGUcECmhKSLTmJbes5AXFKGOWKV5SasgIoP1d45sQvC1l612l_FYiKHda5B8tsXOz77S9rmxxbBw8xPz2kKtg1Lr0qjYuHDEmmBA5jVi6x1wUtTnGyq9kzgijMp--y8WM5PhhPpeLyJPDq6rS3hXfVi6b3tdRzz_P_gKes4iJ</recordid><startdate>198609</startdate><enddate>198609</enddate><creator>Holdstein, Y.</creator><creator>Pratt, H.</creator><creator>Goldsher, M.</creator><creator>Rosen, G.</creator><creator>Shenhav, R.</creator><creator>Linn, S.</creator><creator>Mor, A.</creator><creator>Barkai, A.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198609</creationdate><title>Auditory brainstem evoked potentials in asymptomatic lead-exposed subjects</title><author>Holdstein, Y. ; Pratt, H. ; Goldsher, M. ; Rosen, G. ; Shenhav, R. ; Linn, S. ; Mor, A. ; Barkai, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-b3eeca4b95693839488c3d592b5e5a4813090cf03bb8f8e7f8d52147e7a8f55c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brain Stem - physiopathology</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Child</topic><topic>Evoked Potentials, Auditory - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Lead Poisoning - diagnosis</topic><topic>Lead Poisoning - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Middle Aged</topic><topic>Time Factors</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holdstein, Y.</creatorcontrib><creatorcontrib>Pratt, H.</creatorcontrib><creatorcontrib>Goldsher, M.</creatorcontrib><creatorcontrib>Rosen, G.</creatorcontrib><creatorcontrib>Shenhav, R.</creatorcontrib><creatorcontrib>Linn, S.</creatorcontrib><creatorcontrib>Mor, A.</creatorcontrib><creatorcontrib>Barkai, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holdstein, Y.</au><au>Pratt, H.</au><au>Goldsher, M.</au><au>Rosen, G.</au><au>Shenhav, R.</au><au>Linn, S.</au><au>Mor, A.</au><au>Barkai, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Auditory brainstem evoked potentials in asymptomatic lead-exposed subjects</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. Laryngol. Otol</addtitle><date>1986-09</date><risdate>1986</risdate><volume>100</volume><issue>9</issue><spage>1031</spage><epage>1036</epage><pages>1031-1036</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><coden>JLOTAX</coden><abstract>Auditory Brainstem Evoked Potentials (ABEP) were recorded from 29 adults and children, accidentally exposed to lead through food until approximately a year prior to this study. ABEP were recorded in response to 75 dBHL click presented at rates of 10/sec. and 55/sec. Average values were calculated for peak latency and for interpeak latency differences. Average values of the effect of increasing stimulus rate were calculated as well. Similar values were calculated for normative child and adult control groups. IPLD (I-III) showed the most significant and recurring results, with longer intervals in lead-exposed children compared with their control group. Increasing stimulus rate, on the other hand, affected the adult lead-exposed subjects more than the children. These results may imply an impairment of the auditory system with azonal and myelin involvement. ABEP is suggested as a sensitive detector of subclinical lead exposure effects on the nervous system.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>3760684</pmid><doi>10.1017/S0022215100100519</doi><tpages>6</tpages></addata></record> |
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subjects | Adolescent Adult Biological and medical sciences Brain Stem - physiopathology Chemical and industrial products toxicology. Toxic occupational diseases Child Evoked Potentials, Auditory - drug effects Female Humans Lead Poisoning - diagnosis Lead Poisoning - physiopathology Male Medical sciences Metals and various inorganic compounds Middle Aged Time Factors Toxicology |
title | Auditory brainstem evoked potentials in asymptomatic lead-exposed subjects |
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