The synthesis of benzannulated spiroketals from 1,1-diacyl-2-phenylcyclopropanes
[Display omitted] •Donor-acceptor cyclopropanes are useful building blocks in synthesis.•Benzannulated spiroketals were accessed from donor-acceptor cyclopropanes.•Stereochemically rich 5,5 and 6,5-benzanulated spiroketals were synthesised. A new method to access benzannulated spiroketals from 1,1-d...
Gespeichert in:
Veröffentlicht in: | Tetrahedron letters 2021-04, Vol.69, p.152984, Article 152984 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | [Display omitted]
•Donor-acceptor cyclopropanes are useful building blocks in synthesis.•Benzannulated spiroketals were accessed from donor-acceptor cyclopropanes.•Stereochemically rich 5,5 and 6,5-benzanulated spiroketals were synthesised.
A new method to access benzannulated spiroketals from 1,1-diacyl phenylcyclopropanes is described. The method provides rapid access to 5,5 and 5,6-benzannulated spiroketals in low to moderate yields and with moderate to good diastereoselectivity. |
---|---|
ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2021.152984 |