A Heck reaction/photochemical alkene isomerization sequence to prepare functionalized quinolines

A Heck reaction/photochemical alkene isomerization sequence to prepare functionalized quinolines

A route to prepare functionalized quinolines based on a Heck reaction/UV-induced alkene isomerization sequence is described. The method allows for the preparation of quinolines under mild and neutral conditions and has broad functional group tolerance. Acid-sensitive functional groups that would not...

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Veröffentlicht in:Tetrahedron 2020-08, Vol.76 (35), p.131396, Article 131396
Hauptverfasser: Kelly, Alex, Hoffman, Jack B., Hoff, Oskar, Walker, Johannes C.L., Werrel, Simon, Donohoe, Timothy J.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Heck reactions
Photochemical isomerization
Physical Sciences
Quinolines
Science & Technology
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Zusammenfassung:A route to prepare functionalized quinolines based on a Heck reaction/UV-induced alkene isomerization sequence is described. The method allows for the preparation of quinolines under mild and neutral conditions and has broad functional group tolerance. Acid-sensitive functional groups that would not be tolerated under previous approaches can be included and a one-pot quinoline forming procedure is also reported. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2020.131396