Construction of NIR etchable nanoparticles via co-assembly strategy for appointed delivery

NIR etchable nanoparticles were prepared from NIR-triggered molecule (ASBBCM) and short anticancer peptide segment. After NIR irradiation, the surface of nanoparticles became rough according to the TEM observation due to ASBBCM degradation. Since the nanoparticles were gradually destroyed from the surface, functional YSV peptides were released simultaneously. The release rates were closely related to the degree of photo-etching. Cytotoxicity and cell internalization experiments of nanoparticles at different irradiation conditions were carried by MTT, FCM and IFM. In vivo evaluation also proved that the photo-etchable nanoparticles exhibited excellent effectiveness in directed release in the organism. Compared to conventional drug delivery platforms, this research provides the opportunity to develop smarter self-assembled bio-small molecules for precise therapeutic bio-nanomaterials. [Display omitted] •NIR etching is new method for controlling nanostructures.•NIR has a certain subcutaneous irradiation depth, which can realize remote response.•Combined nanostructures and NIR responsiveness, we can realize appoint delivery.•Nanoparticle structures make the drugs easier to internalize into cells.