Advancements in nanozymes research for the management of chronic wounds

[Display omitted] •Nanozymes combine the unique properties of nanomaterials with catalytic functions.•Biomaterial nanozymes effectively enhance the healing of chronic wounds.•The multi-enzyme activities or cascades reactions of nanozymes are utilized for wound therapy.•The loading platforms for nanozymes can enhance the therapeutic effect. Chronic wounds represent a significant global public health concern, imposing substantial burdens on healthcare systems. Moreover, the complex wound microenvironment presents formidable challenges for the treatment of chronic wounds. The development of chronic wounds typically involves a combination of factors, with the most common being bacterial infection, persistent inflammation, oxidative stress, and angiogenic disorders. In recent years, nanozymes have emerged as a potential mimic of enzyme activity, offering new possibilities for effectively treating chronic wounds. By simulating the catalytic activity and specificity of natural biological enzymes, these nanozymes can generate free radicals, regulate redox balance, lower blood sugar levels, and provide oxygen support. As a result, they can enhance antibacterial effects, eliminate reactive oxygen species, reduce inflammation, and promote angiogenesis. This paper reviews the research progress of nanozymes in wound healing including their classification and mechanism as well as various treatment optimization strategies and loading platforms. It aims to serve as a reference and source of inspiration for further research and clinical application in this field by providing a comprehensive summary of nanozymes research in chronic wound healing.