A Molecular, Clinical and Immunohistochemical Study of Vestibular Schwannoma

The molecular pathogenesis of vestibular schwannoma has been investigated by determining the extent of chromosome 22 loss of heterozygosity in 77 tumors and relating these findings to clinical and immunohistochemical indexes of tumor behavior. Loss of heterozygosity was looked for at eight chromosom...

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Veröffentlicht in:	Otolaryngology-head and neck surgery 1997-04, Vol.116 (4), p.426-430
Hauptverfasser:	Irving, Richard M., Moffat, David A., Hardy, David G., Barton, David E., Xuereb, John H., Holland, Fiona J., Maher, Eamonn R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Antibodies, Monoclonal Cell Division Chromosome Deletion Chromosome Mapping Chromosomes, Human, Pair 22 - genetics Ear Neoplasms - genetics Ear Neoplasms - pathology Female Gene Expression Regulation, Neoplastic - genetics Genes, Neurofibromatosis 2 - genetics Heterozygote Humans Immunohistochemistry Male Microsatellite Repeats - genetics Middle Aged Molecular Biology Mutation - genetics Neuroma, Acoustic - genetics Neuroma, Acoustic - pathology Proliferating Cell Nuclear Antigen - analysis Vestibular Diseases - genetics Vestibular Diseases - pathology
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