Synthesis and biological evaluation of novel piperidin-4-ol derivatives

Synthesis and biological evaluation of novel piperidin-4-ol derivatives

A series of novel piperidin-4-ol derivatives were designed, synthesized, and evaluated for potential treatment of HIV. The compounds were obtained via an efficient synthetic route in excellent yields and have been characterized by 1 H NMR, 13 C NMR, MS, and elemental analysis. The CCR5 antagonistic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Monatshefte für Chemie 2012-02, Vol.143 (2), p.303-308
Hauptverfasser: Weng, Zhiyong, Wei, Wei, Dong, Xiaowu, Hu, Yongzhou, Huang, Shufang, Liu, Tao, Xie, Xin
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A series of novel piperidin-4-ol derivatives were designed, synthesized, and evaluated for potential treatment of HIV. The compounds were obtained via an efficient synthetic route in excellent yields and have been characterized by 1 H NMR, 13 C NMR, MS, and elemental analysis. The CCR5 antagonistic activities of the compounds have also been evaluated. Graphical abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-011-0645-9