Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate
The efficacies of diloxanide furoate, beta-cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infec...
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| Veröffentlicht in: | Parasitology research (1987) 2001-06, Vol.87 (6), p.449-452 |
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| container_end_page | 452 |
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| container_issue | 6 |
| container_start_page | 449 |
| container_title | Parasitology research (1987) |
| container_volume | 87 |
| creator | CASTRO HERMIDA, J. A ARES-MAZAS, M. E NIETO REYES, L OTERO ESPINAR, F BLANCO MENDEZ, J |
| description | The efficacies of diloxanide furoate, beta-cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta-cyclodextrin, an excipient used in pharmaceutical technology. |
| doi_str_mv | 10.1007/s004360000359 |
| format | Article |
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The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta-cyclodextrin, an excipient used in pharmaceutical technology.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s004360000359</identifier><identifier>PMID: 11411943</identifier><identifier>CODEN: PARREZ</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Amebicides - therapeutic use ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; beta-Cyclodextrins ; Biological and medical sciences ; Cattle ; Cryptosporidiosis - drug therapy ; Cryptosporidiosis - parasitology ; Cryptosporidium parvum - isolation & purification ; Cryptosporidium parvum - physiology ; Cyclodextrins - therapeutic use ; Disease Models, Animal ; Drug Carriers ; Drug Therapy, Combination ; Excipients ; Furans - therapeutic use ; Medical sciences ; Mice ; Parasite Egg Count ; Pharmacology. 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Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>beta-Cyclodextrins</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cryptosporidiosis - drug therapy</subject><subject>Cryptosporidiosis - parasitology</subject><subject>Cryptosporidium parvum - isolation & purification</subject><subject>Cryptosporidium parvum - physiology</subject><subject>Cyclodextrins - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Drug Carriers</subject><subject>Drug Therapy, Combination</subject><subject>Excipients</subject><subject>Furans - therapeutic use</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Parasite Egg Count</subject><subject>Pharmacology. 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Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>beta-Cyclodextrins</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cryptosporidiosis - drug therapy</topic><topic>Cryptosporidiosis - parasitology</topic><topic>Cryptosporidium parvum - isolation & purification</topic><topic>Cryptosporidium parvum - physiology</topic><topic>Cyclodextrins - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Drug Carriers</topic><topic>Drug Therapy, Combination</topic><topic>Excipients</topic><topic>Furans - therapeutic use</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Parasite Egg Count</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CASTRO HERMIDA, J. A</creatorcontrib><creatorcontrib>ARES-MAZAS, M. 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| fulltext | fulltext |
| identifier | ISSN: 0932-0113 |
| ispartof | Parasitology research (1987), 2001-06, Vol.87 (6), p.449-452 |
| issn | 0932-0113 1432-1955 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_s004360000359 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Amebicides - therapeutic use Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents beta-Cyclodextrins Biological and medical sciences Cattle Cryptosporidiosis - drug therapy Cryptosporidiosis - parasitology Cryptosporidium parvum - isolation & purification Cryptosporidium parvum - physiology Cyclodextrins - therapeutic use Disease Models, Animal Drug Carriers Drug Therapy, Combination Excipients Furans - therapeutic use Medical sciences Mice Parasite Egg Count Pharmacology. Drug treatments |
| title | Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate |
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