Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C
In experiments using the renal carcinogen ferric nitrilotriacetate (Fe-NTA) in male ddY mice, primary pulmonary cancers were also induced in bronchiolar and alveolar tissues. 4-Hydroxy-2-nonenal (4-HNE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), products of oxidative processes, increased in bron...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2001-03, Vol.438 (3), p.259-270 |
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| container_title | Virchows Archiv : an international journal of pathology |
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| creator | KIMOTO, Tetsuo KOYA-MIYATA, Satomi HINO, Keiko MICALLEF, Mark J HANAYA, Toshiharu ARAI, Shigeyuki IKEDA, Masao KURIMOTO, Masashi |
| description | In experiments using the renal carcinogen ferric nitrilotriacetate (Fe-NTA) in male ddY mice, primary pulmonary cancers were also induced in bronchiolar and alveolar tissues. 4-Hydroxy-2-nonenal (4-HNE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), products of oxidative processes, increased in bronchiolar and alveolar cells after administration of Fe-NTA. These substances disappeared after oral administration of propolis or artepillin C, as shown histochemically, and correlated with an anticancer prophylactic effect of propolis and artepillin C. From our investigation, lipid peroxidation seems to play an important role in pulmonary carcinogenesis. Malignant progression from adenoma of bronchiolar or alveolar origin to malignant tumors has been proposed to involve a stepwise transformation. In our study, adenomas developed into adenocarcinomas and large cell carcinomas after treatment with Fe-NTA. In contrast, after oral administration of propolis or artepillin C, adenomas did not progress to carcinomas. Instead of developing into large cell cancers, as induced by Fe-NTA in control mice, adenomas showed remarkable proliferation of macrophages and local anti-oxidant activity after treatment with either propolis or artepillin C. Propolis and artepillin C therefore appear to inhibit lipid peroxidation and the development of pulmonary cancers. |
| doi_str_mv | 10.1007/s004280000350 |
| format | Article |
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These substances disappeared after oral administration of propolis or artepillin C, as shown histochemically, and correlated with an anticancer prophylactic effect of propolis and artepillin C. From our investigation, lipid peroxidation seems to play an important role in pulmonary carcinogenesis. Malignant progression from adenoma of bronchiolar or alveolar origin to malignant tumors has been proposed to involve a stepwise transformation. In our study, adenomas developed into adenocarcinomas and large cell carcinomas after treatment with Fe-NTA. In contrast, after oral administration of propolis or artepillin C, adenomas did not progress to carcinomas. Instead of developing into large cell cancers, as induced by Fe-NTA in control mice, adenomas showed remarkable proliferation of macrophages and local anti-oxidant activity after treatment with either propolis or artepillin C. Propolis and artepillin C therefore appear to inhibit lipid peroxidation and the development of pulmonary cancers.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s004280000350</identifier><identifier>PMID: 11315623</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Aldehydes - analysis ; Animal tumors. Experimental tumors ; Animals ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - analysis ; Experimental respiratory system tumors ; Ferric Compounds - toxicity ; Immunohistochemistry ; Lipid Peroxidation - drug effects ; Lung Neoplasms - chemically induced ; Lung Neoplasms - pathology ; Lung Neoplasms - prevention & control ; Male ; Medical sciences ; Mice ; Nitrilotriacetic Acid - analogs & derivatives ; Nitrilotriacetic Acid - toxicity ; Nuclear Proteins - analysis ; Phenylpropionates - pharmacology ; Proliferating Cell Nuclear Antigen - analysis ; Propolis - pharmacology ; Thyroid Nuclear Factor 1 ; Transcription Factors - analysis ; Tumors</subject><ispartof>Virchows Archiv : an international journal of pathology, 2001-03, Vol.438 (3), p.259-270</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-ff840bbc3aeb8804b1ed4833830f3f89c89afe2232e9a7d07b2324a320c3aadc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=902381$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11315623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIMOTO, Tetsuo</creatorcontrib><creatorcontrib>KOYA-MIYATA, Satomi</creatorcontrib><creatorcontrib>HINO, Keiko</creatorcontrib><creatorcontrib>MICALLEF, Mark J</creatorcontrib><creatorcontrib>HANAYA, Toshiharu</creatorcontrib><creatorcontrib>ARAI, Shigeyuki</creatorcontrib><creatorcontrib>IKEDA, Masao</creatorcontrib><creatorcontrib>KURIMOTO, Masashi</creatorcontrib><title>Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><description>In experiments using the renal carcinogen ferric nitrilotriacetate (Fe-NTA) in male ddY mice, primary pulmonary cancers were also induced in bronchiolar and alveolar tissues. 4-Hydroxy-2-nonenal (4-HNE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), products of oxidative processes, increased in bronchiolar and alveolar cells after administration of Fe-NTA. These substances disappeared after oral administration of propolis or artepillin C, as shown histochemically, and correlated with an anticancer prophylactic effect of propolis and artepillin C. From our investigation, lipid peroxidation seems to play an important role in pulmonary carcinogenesis. Malignant progression from adenoma of bronchiolar or alveolar origin to malignant tumors has been proposed to involve a stepwise transformation. In our study, adenomas developed into adenocarcinomas and large cell carcinomas after treatment with Fe-NTA. In contrast, after oral administration of propolis or artepillin C, adenomas did not progress to carcinomas. Instead of developing into large cell cancers, as induced by Fe-NTA in control mice, adenomas showed remarkable proliferation of macrophages and local anti-oxidant activity after treatment with either propolis or artepillin C. Propolis and artepillin C therefore appear to inhibit lipid peroxidation and the development of pulmonary cancers.</description><subject>Aldehydes - analysis</subject><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - analysis</subject><subject>Experimental respiratory system tumors</subject><subject>Ferric Compounds - toxicity</subject><subject>Immunohistochemistry</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lung Neoplasms - chemically induced</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Nitrilotriacetic Acid - analogs & derivatives</subject><subject>Nitrilotriacetic Acid - toxicity</subject><subject>Nuclear Proteins - analysis</subject><subject>Phenylpropionates - pharmacology</subject><subject>Proliferating Cell Nuclear Antigen - analysis</subject><subject>Propolis - pharmacology</subject><subject>Thyroid Nuclear Factor 1</subject><subject>Transcription Factors - analysis</subject><subject>Tumors</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1LxDAQxYMo7rp69CoBz9VJ0t2mR138ggU96LlM00QibVKS7EGP_uWm7KI4h5mB-c2D9wg5Z3DFAKrrCFByCbnEEg7InJWCF1xAdUjmUJfLYiVYNSMnMX4AcCbZ6pjMGBNsueJiTr5ftv3gHYZPqjAo6_y7djraSK3rtkp3tP2kRodgFXU2Bdv73FDphElnhg5WaYquo2PwSatkvaMm-IHaNL3eBvyyvUU33UffZ-EJxpD0aPs-C6xPyZHBPuqz_VyQt_u71_VjsXl-eFrfbAqVHaTCGFlC2yqBupUSypbprpRCSAFGGFkrWaPRnAuua6w6qNq8lig45BfslFiQYqergo8xaNOMwQ7ZecOgmbJs_mWZ-YsdP27bQXd_9D68DFzuAYwKexPQKRt_uRq4kEz8AGgmfkU</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>KIMOTO, Tetsuo</creator><creator>KOYA-MIYATA, Satomi</creator><creator>HINO, Keiko</creator><creator>MICALLEF, Mark J</creator><creator>HANAYA, Toshiharu</creator><creator>ARAI, Shigeyuki</creator><creator>IKEDA, Masao</creator><creator>KURIMOTO, Masashi</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010301</creationdate><title>Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C</title><author>KIMOTO, Tetsuo ; KOYA-MIYATA, Satomi ; HINO, Keiko ; MICALLEF, Mark J ; HANAYA, Toshiharu ; ARAI, Shigeyuki ; IKEDA, Masao ; KURIMOTO, Masashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-ff840bbc3aeb8804b1ed4833830f3f89c89afe2232e9a7d07b2324a320c3aadc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aldehydes - analysis</topic><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Deoxyguanosine - analogs & derivatives</topic><topic>Deoxyguanosine - analysis</topic><topic>Experimental respiratory system tumors</topic><topic>Ferric Compounds - toxicity</topic><topic>Immunohistochemistry</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lung Neoplasms - chemically induced</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - prevention & control</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Nitrilotriacetic Acid - analogs & derivatives</topic><topic>Nitrilotriacetic Acid - toxicity</topic><topic>Nuclear Proteins - analysis</topic><topic>Phenylpropionates - pharmacology</topic><topic>Proliferating Cell Nuclear Antigen - analysis</topic><topic>Propolis - pharmacology</topic><topic>Thyroid Nuclear Factor 1</topic><topic>Transcription Factors - analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIMOTO, Tetsuo</creatorcontrib><creatorcontrib>KOYA-MIYATA, Satomi</creatorcontrib><creatorcontrib>HINO, Keiko</creatorcontrib><creatorcontrib>MICALLEF, Mark J</creatorcontrib><creatorcontrib>HANAYA, Toshiharu</creatorcontrib><creatorcontrib>ARAI, Shigeyuki</creatorcontrib><creatorcontrib>IKEDA, Masao</creatorcontrib><creatorcontrib>KURIMOTO, Masashi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIMOTO, Tetsuo</au><au>KOYA-MIYATA, Satomi</au><au>HINO, Keiko</au><au>MICALLEF, Mark J</au><au>HANAYA, Toshiharu</au><au>ARAI, Shigeyuki</au><au>IKEDA, Masao</au><au>KURIMOTO, Masashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><addtitle>Virchows Arch</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>438</volume><issue>3</issue><spage>259</spage><epage>270</epage><pages>259-270</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>In experiments using the renal carcinogen ferric nitrilotriacetate (Fe-NTA) in male ddY mice, primary pulmonary cancers were also induced in bronchiolar and alveolar tissues. 4-Hydroxy-2-nonenal (4-HNE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), products of oxidative processes, increased in bronchiolar and alveolar cells after administration of Fe-NTA. These substances disappeared after oral administration of propolis or artepillin C, as shown histochemically, and correlated with an anticancer prophylactic effect of propolis and artepillin C. From our investigation, lipid peroxidation seems to play an important role in pulmonary carcinogenesis. Malignant progression from adenoma of bronchiolar or alveolar origin to malignant tumors has been proposed to involve a stepwise transformation. In our study, adenomas developed into adenocarcinomas and large cell carcinomas after treatment with Fe-NTA. In contrast, after oral administration of propolis or artepillin C, adenomas did not progress to carcinomas. Instead of developing into large cell cancers, as induced by Fe-NTA in control mice, adenomas showed remarkable proliferation of macrophages and local anti-oxidant activity after treatment with either propolis or artepillin C. Propolis and artepillin C therefore appear to inhibit lipid peroxidation and the development of pulmonary cancers.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11315623</pmid><doi>10.1007/s004280000350</doi><tpages>12</tpages></addata></record> |
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| subjects | Aldehydes - analysis Animal tumors. Experimental tumors Animals Antineoplastic Agents - pharmacology Biological and medical sciences Deoxyguanosine - analogs & derivatives Deoxyguanosine - analysis Experimental respiratory system tumors Ferric Compounds - toxicity Immunohistochemistry Lipid Peroxidation - drug effects Lung Neoplasms - chemically induced Lung Neoplasms - pathology Lung Neoplasms - prevention & control Male Medical sciences Mice Nitrilotriacetic Acid - analogs & derivatives Nitrilotriacetic Acid - toxicity Nuclear Proteins - analysis Phenylpropionates - pharmacology Proliferating Cell Nuclear Antigen - analysis Propolis - pharmacology Thyroid Nuclear Factor 1 Transcription Factors - analysis Tumors |
| title | Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C |
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