Thyroid function in lead smelter workers : absence of subacute or cumulative effects with moderate lead burdens
To evaluate the effect of low to moderate occupational lead exposure on thyroid function we conducted a cross-sectional study of 151 male lead smelter workers. Parameters of thyroid function were assessed in relation to both subacute and cumulative lead exposure over a 10-year employment period. Blo...
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| Veröffentlicht in: | International archives of occupational and environmental health 1998-10, Vol.71 (7), p.453-458 |
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| creator | SCHUMACHER, C BRODKIN, C. A ALEXANDER, B CULLEN, M RAINEY, P. M VAN NETTEN, C FAUSTMAN, E CHECKOWAY, H |
| description | To evaluate the effect of low to moderate occupational lead exposure on thyroid function we conducted a cross-sectional study of 151 male lead smelter workers.
Parameters of thyroid function were assessed in relation to both subacute and cumulative lead exposure over a 10-year employment period. Blood lead levels, obtained from plant surveillance records, were used to establish four ordinal levels of current and cumulative exposure (< 15, 15-24, 25-39, and > or =40 microg/dl).
Mean values for the lowest as compared with the highest current exposure group were similar for thyroxine (T4: 6.8 versus 6.1 microg/dl), estimated free thyroxine (EFT4: 1.6 ng/dl in both groups), and thyroid-stimulating hormone (TSH: 1.8 versus 1.7 mIU/l); there was no evidence of a significant trend for diminished thyroid function associated with increasing current lead exposure. Similarly, no significant difference was observed for T4, EFT4, or TSH in relation to the 10-year cumulative exposure or for adjusted analyses controlling for potential confounders, including age and alcohol use.
In contrast to studies observing thyroid dysfunction in the setting of high lead exposure and related clinical poisoning, our findings weigh against a significant physiologic effect on thyroid function at lower levels (< 60 microg/dl) of occupational lead exposure. |
| doi_str_mv | 10.1007/s004200050305 |
| format | Article |
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Parameters of thyroid function were assessed in relation to both subacute and cumulative lead exposure over a 10-year employment period. Blood lead levels, obtained from plant surveillance records, were used to establish four ordinal levels of current and cumulative exposure (< 15, 15-24, 25-39, and > or =40 microg/dl).
Mean values for the lowest as compared with the highest current exposure group were similar for thyroxine (T4: 6.8 versus 6.1 microg/dl), estimated free thyroxine (EFT4: 1.6 ng/dl in both groups), and thyroid-stimulating hormone (TSH: 1.8 versus 1.7 mIU/l); there was no evidence of a significant trend for diminished thyroid function associated with increasing current lead exposure. Similarly, no significant difference was observed for T4, EFT4, or TSH in relation to the 10-year cumulative exposure or for adjusted analyses controlling for potential confounders, including age and alcohol use.
In contrast to studies observing thyroid dysfunction in the setting of high lead exposure and related clinical poisoning, our findings weigh against a significant physiologic effect on thyroid function at lower levels (< 60 microg/dl) of occupational lead exposure.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s004200050305</identifier><identifier>PMID: 9826077</identifier><identifier>CODEN: IAEHDW</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Confounding Factors (Epidemiology) ; Cross-Sectional Studies ; Environmental Monitoring - methods ; Humans ; Lead Poisoning - blood ; Lead Poisoning - complications ; Male ; Medical sciences ; Metallurgy ; Metals and various inorganic compounds ; Occupational Diseases - blood ; Occupational Diseases - complications ; Occupational Exposure - adverse effects ; Prevalence ; Thyroid Diseases - chemically induced ; Thyroid Function Tests ; Thyrotropin - blood ; Thyroxine - blood ; Time Factors ; Toxicology</subject><ispartof>International archives of occupational and environmental health, 1998-10, Vol.71 (7), p.453-458</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-e97db70d466868d35d23b84e44681ef0a981b7e26bea34a58436835ab541e8773</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1603384$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9826077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHUMACHER, C</creatorcontrib><creatorcontrib>BRODKIN, C. A</creatorcontrib><creatorcontrib>ALEXANDER, B</creatorcontrib><creatorcontrib>CULLEN, M</creatorcontrib><creatorcontrib>RAINEY, P. M</creatorcontrib><creatorcontrib>VAN NETTEN, C</creatorcontrib><creatorcontrib>FAUSTMAN, E</creatorcontrib><creatorcontrib>CHECKOWAY, H</creatorcontrib><title>Thyroid function in lead smelter workers : absence of subacute or cumulative effects with moderate lead burdens</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><description>To evaluate the effect of low to moderate occupational lead exposure on thyroid function we conducted a cross-sectional study of 151 male lead smelter workers.
Parameters of thyroid function were assessed in relation to both subacute and cumulative lead exposure over a 10-year employment period. Blood lead levels, obtained from plant surveillance records, were used to establish four ordinal levels of current and cumulative exposure (< 15, 15-24, 25-39, and > or =40 microg/dl).
Mean values for the lowest as compared with the highest current exposure group were similar for thyroxine (T4: 6.8 versus 6.1 microg/dl), estimated free thyroxine (EFT4: 1.6 ng/dl in both groups), and thyroid-stimulating hormone (TSH: 1.8 versus 1.7 mIU/l); there was no evidence of a significant trend for diminished thyroid function associated with increasing current lead exposure. Similarly, no significant difference was observed for T4, EFT4, or TSH in relation to the 10-year cumulative exposure or for adjusted analyses controlling for potential confounders, including age and alcohol use.
In contrast to studies observing thyroid dysfunction in the setting of high lead exposure and related clinical poisoning, our findings weigh against a significant physiologic effect on thyroid function at lower levels (< 60 microg/dl) of occupational lead exposure.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Confounding Factors (Epidemiology)</subject><subject>Cross-Sectional Studies</subject><subject>Environmental Monitoring - methods</subject><subject>Humans</subject><subject>Lead Poisoning - blood</subject><subject>Lead Poisoning - complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metallurgy</subject><subject>Metals and various inorganic compounds</subject><subject>Occupational Diseases - blood</subject><subject>Occupational Diseases - complications</subject><subject>Occupational Exposure - adverse effects</subject><subject>Prevalence</subject><subject>Thyroid Diseases - chemically induced</subject><subject>Thyroid Function Tests</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Time Factors</subject><subject>Toxicology</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLAzEUhYMotVaXLoUs3I7eTDJJ6k6KLyi4qeshjxs6Oo-SzFj67x1tUVzdA-fj43IIuWRwwwDUbQIQOQAUwKE4IlMmeJ6xXMhjMgUuIAPG2Sk5S-kdgCmp-IRM5jqXoNSUdKv1LnaVp2FoXV91La1aWqPxNDVY9xjptosfGBO9o8YmbB3SLtA0WOOGfsyRuqEZatNXn0gxBHR9otuqX9Om8xjNyPzo7BA9tumcnARTJ7w43Bl5e3xYLZ6z5evTy-J-mTnOVJ_hXHmrwAsptdSeFz7nVgsUQmqGAcxcM6swlxYNF6bQgkvNC2MLwVArxWck23td7FKKGMpNrBoTdyWD8nu38t9uI3-15zeDbdD_0oehxv760JvkTB2iaV2V_qQSOB-f-AIb1nVY</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>SCHUMACHER, C</creator><creator>BRODKIN, C. 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M ; VAN NETTEN, C ; FAUSTMAN, E ; CHECKOWAY, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-e97db70d466868d35d23b84e44681ef0a981b7e26bea34a58436835ab541e8773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Confounding Factors (Epidemiology)</topic><topic>Cross-Sectional Studies</topic><topic>Environmental Monitoring - methods</topic><topic>Humans</topic><topic>Lead Poisoning - blood</topic><topic>Lead Poisoning - complications</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metallurgy</topic><topic>Metals and various inorganic compounds</topic><topic>Occupational Diseases - blood</topic><topic>Occupational Diseases - complications</topic><topic>Occupational Exposure - adverse effects</topic><topic>Prevalence</topic><topic>Thyroid Diseases - chemically induced</topic><topic>Thyroid Function Tests</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Time Factors</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHUMACHER, C</creatorcontrib><creatorcontrib>BRODKIN, C. A</creatorcontrib><creatorcontrib>ALEXANDER, B</creatorcontrib><creatorcontrib>CULLEN, M</creatorcontrib><creatorcontrib>RAINEY, P. M</creatorcontrib><creatorcontrib>VAN NETTEN, C</creatorcontrib><creatorcontrib>FAUSTMAN, E</creatorcontrib><creatorcontrib>CHECKOWAY, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International archives of occupational and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHUMACHER, C</au><au>BRODKIN, C. A</au><au>ALEXANDER, B</au><au>CULLEN, M</au><au>RAINEY, P. M</au><au>VAN NETTEN, C</au><au>FAUSTMAN, E</au><au>CHECKOWAY, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid function in lead smelter workers : absence of subacute or cumulative effects with moderate lead burdens</atitle><jtitle>International archives of occupational and environmental health</jtitle><addtitle>Int Arch Occup Environ Health</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>71</volume><issue>7</issue><spage>453</spage><epage>458</epage><pages>453-458</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><coden>IAEHDW</coden><abstract>To evaluate the effect of low to moderate occupational lead exposure on thyroid function we conducted a cross-sectional study of 151 male lead smelter workers.
Parameters of thyroid function were assessed in relation to both subacute and cumulative lead exposure over a 10-year employment period. Blood lead levels, obtained from plant surveillance records, were used to establish four ordinal levels of current and cumulative exposure (< 15, 15-24, 25-39, and > or =40 microg/dl).
Mean values for the lowest as compared with the highest current exposure group were similar for thyroxine (T4: 6.8 versus 6.1 microg/dl), estimated free thyroxine (EFT4: 1.6 ng/dl in both groups), and thyroid-stimulating hormone (TSH: 1.8 versus 1.7 mIU/l); there was no evidence of a significant trend for diminished thyroid function associated with increasing current lead exposure. Similarly, no significant difference was observed for T4, EFT4, or TSH in relation to the 10-year cumulative exposure or for adjusted analyses controlling for potential confounders, including age and alcohol use.
In contrast to studies observing thyroid dysfunction in the setting of high lead exposure and related clinical poisoning, our findings weigh against a significant physiologic effect on thyroid function at lower levels (< 60 microg/dl) of occupational lead exposure.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9826077</pmid><doi>10.1007/s004200050305</doi><tpages>6</tpages></addata></record> |
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| ispartof | International archives of occupational and environmental health, 1998-10, Vol.71 (7), p.453-458 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Confounding Factors (Epidemiology) Cross-Sectional Studies Environmental Monitoring - methods Humans Lead Poisoning - blood Lead Poisoning - complications Male Medical sciences Metallurgy Metals and various inorganic compounds Occupational Diseases - blood Occupational Diseases - complications Occupational Exposure - adverse effects Prevalence Thyroid Diseases - chemically induced Thyroid Function Tests Thyrotropin - blood Thyroxine - blood Time Factors Toxicology |
| title | Thyroid function in lead smelter workers : absence of subacute or cumulative effects with moderate lead burdens |
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