Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials
We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms and cognition across six chronic brain disorders: Alzheimer’s disease, Huntington’s disease, multiple sclerosis, Pa...
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| Veröffentlicht in: | Journal of neurology 2021-04, Vol.268 (4), p.1222-1246 |
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| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms and cognition across six chronic brain disorders: Alzheimer’s disease, Huntington’s disease, multiple sclerosis, Parkinson’s disease, schizophrenia and unipolar depression. 122 studies ( =
k
) (
n
= 7231) were included. Exercise was superior to treatment as usual in improving QoL (
k
= 64,
n
= 4334, ES = 0.40,
p
|
|---|---|
| ISSN: | 0340-5354 1432-1459 1432-1459 |
| DOI: | 10.1007/s00415-019-09493-9 |