Experience with pineal region tumors

The results are reported of a retrospective review of the presentation and outcome of 43 pineal region tumors treated from 1982 to 1996, including 20 identified tumors: 5 germinomas, 8 teratomas, 2 embryonal carcinomas, 1 endodermal sinus tumor, 2 pineocytomas and 2 pineoblastomas. Of the 43 tumors...

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Veröffentlicht in:Child's nervous system 1998-01, Vol.14 (1-2), p.63-68
Hauptverfasser: Kang, J K, Jeun, S S, Hong, Y K, Park, C K, Son, B C, Lee, I W, Kim, M C
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container_issue 1-2
container_start_page 63
container_title Child's nervous system
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creator Kang, J K
Jeun, S S
Hong, Y K
Park, C K
Son, B C
Lee, I W
Kim, M C
description The results are reported of a retrospective review of the presentation and outcome of 43 pineal region tumors treated from 1982 to 1996, including 20 identified tumors: 5 germinomas, 8 teratomas, 2 embryonal carcinomas, 1 endodermal sinus tumor, 2 pineocytomas and 2 pineoblastomas. Of the 43 tumors reviewed, 36 were located in the pineal region, 5 in the suprasellar, and 2 in both the pineal and suprasellar regions. Twenty patients underwent surgical resection: total in 6 and partial in 10, while only a biopsy was taken in 4 cases. Fifteen patients were managed on the basis of serum CSF tumor markers and radiation response. Twenty-three patients with germinomas received radiotherapy (RT) and had a 5-year survival rate of 87%. Fifteen patients with non-germinomatous germ cell tumors received RT and chemotherapy following direct surgery, and 5 died (mortality rate of 33.3%). The overall survival rate of the 43 patients with pineal tumors was 79.1% (34/43) and the death rate was 20.9% (9/43). It is now recognized that the wide variety of tumor types found in the pineal region necessitates different modes of treatment, and improved microsurgical and stereotactic surgical techniques have made mortality and morbidity rates acceptably low. Because the radiation response and CSF cytology are not enough to determine optimum treatment, a tissue diagnosis should be obtained in all patients.
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Of the 43 tumors reviewed, 36 were located in the pineal region, 5 in the suprasellar, and 2 in both the pineal and suprasellar regions. Twenty patients underwent surgical resection: total in 6 and partial in 10, while only a biopsy was taken in 4 cases. Fifteen patients were managed on the basis of serum CSF tumor markers and radiation response. Twenty-three patients with germinomas received radiotherapy (RT) and had a 5-year survival rate of 87%. Fifteen patients with non-germinomatous germ cell tumors received RT and chemotherapy following direct surgery, and 5 died (mortality rate of 33.3%). The overall survival rate of the 43 patients with pineal tumors was 79.1% (34/43) and the death rate was 20.9% (9/43). It is now recognized that the wide variety of tumor types found in the pineal region necessitates different modes of treatment, and improved microsurgical and stereotactic surgical techniques have made mortality and morbidity rates acceptably low. 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source MEDLINE; Springer Nature - Complete Springer Journals
subjects Adolescent
Adult
Biological and medical sciences
Biomarkers, Tumor - cerebrospinal fluid
Brain Neoplasms - diagnosis
Brain Neoplasms - mortality
Brain Neoplasms - radiotherapy
Brain Neoplasms - surgery
Child
Child, Preschool
Combined Modality Therapy
Cranial Irradiation
Endocrine glands
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Pineal Gland - pathology
Pineal Gland - surgery
Pinealoma - diagnosis
Pinealoma - mortality
Pinealoma - radiotherapy
Pinealoma - surgery
Radiation Dosage
Radiotherapy, Adjuvant
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Retrospective Studies
Survival Rate
Tomography, X-Ray Computed
Tropical medicine
title Experience with pineal region tumors
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