Experience with pineal region tumors
The results are reported of a retrospective review of the presentation and outcome of 43 pineal region tumors treated from 1982 to 1996, including 20 identified tumors: 5 germinomas, 8 teratomas, 2 embryonal carcinomas, 1 endodermal sinus tumor, 2 pineocytomas and 2 pineoblastomas. Of the 43 tumors...
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Veröffentlicht in: | Child's nervous system 1998-01, Vol.14 (1-2), p.63-68 |
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description | The results are reported of a retrospective review of the presentation and outcome of 43 pineal region tumors treated from 1982 to 1996, including 20 identified tumors: 5 germinomas, 8 teratomas, 2 embryonal carcinomas, 1 endodermal sinus tumor, 2 pineocytomas and 2 pineoblastomas. Of the 43 tumors reviewed, 36 were located in the pineal region, 5 in the suprasellar, and 2 in both the pineal and suprasellar regions. Twenty patients underwent surgical resection: total in 6 and partial in 10, while only a biopsy was taken in 4 cases. Fifteen patients were managed on the basis of serum CSF tumor markers and radiation response. Twenty-three patients with germinomas received radiotherapy (RT) and had a 5-year survival rate of 87%. Fifteen patients with non-germinomatous germ cell tumors received RT and chemotherapy following direct surgery, and 5 died (mortality rate of 33.3%). The overall survival rate of the 43 patients with pineal tumors was 79.1% (34/43) and the death rate was 20.9% (9/43). It is now recognized that the wide variety of tumor types found in the pineal region necessitates different modes of treatment, and improved microsurgical and stereotactic surgical techniques have made mortality and morbidity rates acceptably low. Because the radiation response and CSF cytology are not enough to determine optimum treatment, a tissue diagnosis should be obtained in all patients. |
doi_str_mv | 10.1007/s003810050177 |
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Of the 43 tumors reviewed, 36 were located in the pineal region, 5 in the suprasellar, and 2 in both the pineal and suprasellar regions. Twenty patients underwent surgical resection: total in 6 and partial in 10, while only a biopsy was taken in 4 cases. Fifteen patients were managed on the basis of serum CSF tumor markers and radiation response. Twenty-three patients with germinomas received radiotherapy (RT) and had a 5-year survival rate of 87%. Fifteen patients with non-germinomatous germ cell tumors received RT and chemotherapy following direct surgery, and 5 died (mortality rate of 33.3%). The overall survival rate of the 43 patients with pineal tumors was 79.1% (34/43) and the death rate was 20.9% (9/43). It is now recognized that the wide variety of tumor types found in the pineal region necessitates different modes of treatment, and improved microsurgical and stereotactic surgical techniques have made mortality and morbidity rates acceptably low. Because the radiation response and CSF cytology are not enough to determine optimum treatment, a tissue diagnosis should be obtained in all patients.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s003810050177</identifier><identifier>PMID: 9548344</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Biomarkers, Tumor - cerebrospinal fluid ; Brain Neoplasms - diagnosis ; Brain Neoplasms - mortality ; Brain Neoplasms - radiotherapy ; Brain Neoplasms - surgery ; Child ; Child, Preschool ; Combined Modality Therapy ; Cranial Irradiation ; Endocrine glands ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Pineal Gland - pathology ; Pineal Gland - surgery ; Pinealoma - diagnosis ; Pinealoma - mortality ; Pinealoma - radiotherapy ; Pinealoma - surgery ; Radiation Dosage ; Radiotherapy, Adjuvant ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Retrospective Studies ; Survival Rate ; Tomography, X-Ray Computed ; Tropical medicine</subject><ispartof>Child's nervous system, 1998-01, Vol.14 (1-2), p.63-68</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-6967113b89d8f861320ea278e97fd13b11c92ad1f60b7a5d6b4b6eab1201bdec3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,777,781,786,787,23911,23912,25121,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2161774$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9548344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, J K</creatorcontrib><creatorcontrib>Jeun, S S</creatorcontrib><creatorcontrib>Hong, Y K</creatorcontrib><creatorcontrib>Park, C K</creatorcontrib><creatorcontrib>Son, B C</creatorcontrib><creatorcontrib>Lee, I W</creatorcontrib><creatorcontrib>Kim, M C</creatorcontrib><title>Experience with pineal region tumors</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><description>The results are reported of a retrospective review of the presentation and outcome of 43 pineal region tumors treated from 1982 to 1996, including 20 identified tumors: 5 germinomas, 8 teratomas, 2 embryonal carcinomas, 1 endodermal sinus tumor, 2 pineocytomas and 2 pineoblastomas. Of the 43 tumors reviewed, 36 were located in the pineal region, 5 in the suprasellar, and 2 in both the pineal and suprasellar regions. Twenty patients underwent surgical resection: total in 6 and partial in 10, while only a biopsy was taken in 4 cases. Fifteen patients were managed on the basis of serum CSF tumor markers and radiation response. Twenty-three patients with germinomas received radiotherapy (RT) and had a 5-year survival rate of 87%. Fifteen patients with non-germinomatous germ cell tumors received RT and chemotherapy following direct surgery, and 5 died (mortality rate of 33.3%). The overall survival rate of the 43 patients with pineal tumors was 79.1% (34/43) and the death rate was 20.9% (9/43). It is now recognized that the wide variety of tumor types found in the pineal region necessitates different modes of treatment, and improved microsurgical and stereotactic surgical techniques have made mortality and morbidity rates acceptably low. Because the radiation response and CSF cytology are not enough to determine optimum treatment, a tissue diagnosis should be obtained in all patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - cerebrospinal fluid</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - mortality</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Brain Neoplasms - surgery</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Cranial Irradiation</subject><subject>Endocrine glands</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pineal Gland - pathology</subject><subject>Pineal Gland - surgery</subject><subject>Pinealoma - diagnosis</subject><subject>Pinealoma - mortality</subject><subject>Pinealoma - radiotherapy</subject><subject>Pinealoma - surgery</subject><subject>Radiation Dosage</subject><subject>Radiotherapy, Adjuvant</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tomography, X-Ray Computed</subject><subject>Tropical medicine</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVj0tLxDAUhYMoYx1duhS6mG313iRN0qUM4wMG3Oi65FWNtJ2SdFD_vZUpA67u4Z6PAx8h1wi3CCDvEgBTUyoBpTwhGXLGCmAlnJIMaCkKCRzOyUVKnwBYKlotyKIquWKcZ2S1-R58DL63Pv8K40c-hN7rNo_-Pez6fNx3u5guyVmj2-Sv5rskbw-b1_VTsX15fF7fbwvLUI6FqIREZEZVTjVKIKPgNZXKV7Jx0x_RVlQ7bAQYqUsnDDfCa4MU0Dhv2ZIUh10bdylF39RDDJ2OPzVC_Sdb_5Od-JsDP-xN592Rnu2mfjX3OlndNlH3NqQjRlFMK5z9AldqWlE</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Kang, J K</creator><creator>Jeun, S S</creator><creator>Hong, Y K</creator><creator>Park, C K</creator><creator>Son, B C</creator><creator>Lee, I W</creator><creator>Kim, M C</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19980101</creationdate><title>Experience with pineal region tumors</title><author>Kang, J K ; Jeun, S S ; Hong, Y K ; Park, C K ; Son, B C ; Lee, I W ; Kim, M C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-6967113b89d8f861320ea278e97fd13b11c92ad1f60b7a5d6b4b6eab1201bdec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - cerebrospinal fluid</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - mortality</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Brain Neoplasms - surgery</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Cranial Irradiation</topic><topic>Endocrine glands</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pineal Gland - pathology</topic><topic>Pineal Gland - surgery</topic><topic>Pinealoma - diagnosis</topic><topic>Pinealoma - mortality</topic><topic>Pinealoma - radiotherapy</topic><topic>Pinealoma - surgery</topic><topic>Radiation Dosage</topic><topic>Radiotherapy, Adjuvant</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tomography, X-Ray Computed</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, J K</creatorcontrib><creatorcontrib>Jeun, S S</creatorcontrib><creatorcontrib>Hong, Y K</creatorcontrib><creatorcontrib>Park, C K</creatorcontrib><creatorcontrib>Son, B C</creatorcontrib><creatorcontrib>Lee, I W</creatorcontrib><creatorcontrib>Kim, M C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, J K</au><au>Jeun, S S</au><au>Hong, Y K</au><au>Park, C K</au><au>Son, B C</au><au>Lee, I W</au><au>Kim, M C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experience with pineal region tumors</atitle><jtitle>Child's nervous system</jtitle><addtitle>Childs Nerv Syst</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>14</volume><issue>1-2</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>The results are reported of a retrospective review of the presentation and outcome of 43 pineal region tumors treated from 1982 to 1996, including 20 identified tumors: 5 germinomas, 8 teratomas, 2 embryonal carcinomas, 1 endodermal sinus tumor, 2 pineocytomas and 2 pineoblastomas. Of the 43 tumors reviewed, 36 were located in the pineal region, 5 in the suprasellar, and 2 in both the pineal and suprasellar regions. Twenty patients underwent surgical resection: total in 6 and partial in 10, while only a biopsy was taken in 4 cases. Fifteen patients were managed on the basis of serum CSF tumor markers and radiation response. Twenty-three patients with germinomas received radiotherapy (RT) and had a 5-year survival rate of 87%. Fifteen patients with non-germinomatous germ cell tumors received RT and chemotherapy following direct surgery, and 5 died (mortality rate of 33.3%). The overall survival rate of the 43 patients with pineal tumors was 79.1% (34/43) and the death rate was 20.9% (9/43). It is now recognized that the wide variety of tumor types found in the pineal region necessitates different modes of treatment, and improved microsurgical and stereotactic surgical techniques have made mortality and morbidity rates acceptably low. Because the radiation response and CSF cytology are not enough to determine optimum treatment, a tissue diagnosis should be obtained in all patients.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9548344</pmid><doi>10.1007/s003810050177</doi><tpages>6</tpages></addata></record> |
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subjects | Adolescent Adult Biological and medical sciences Biomarkers, Tumor - cerebrospinal fluid Brain Neoplasms - diagnosis Brain Neoplasms - mortality Brain Neoplasms - radiotherapy Brain Neoplasms - surgery Child Child, Preschool Combined Modality Therapy Cranial Irradiation Endocrine glands Female Follow-Up Studies Humans Magnetic Resonance Imaging Male Medical sciences Pineal Gland - pathology Pineal Gland - surgery Pinealoma - diagnosis Pinealoma - mortality Pinealoma - radiotherapy Pinealoma - surgery Radiation Dosage Radiotherapy, Adjuvant Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Retrospective Studies Survival Rate Tomography, X-Ray Computed Tropical medicine |
title | Experience with pineal region tumors |
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