Early post-traumatic seizures in children with head injury
Post-traumatic seizures (PTS) can be a serious complication of head injury, because they can cause secondary brain damage through increased metabolic requirements, raised intracranial pressure, cerebral hypoxia, and/or excessive release of neurotransmitters. In children, early PTS are more frequent...
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| Veröffentlicht in: | Child's nervous system 2000-12, Vol.16 (12), p.862-866 |
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| creator | CHIARETTI, Antonio DE BENEDICTIS, Raffaella POLIDORI, Giancarlo PIASTRA, Marco IANNELLI, Aldo DI ROCCO, Concezio |
| description | Post-traumatic seizures (PTS) can be a serious complication of head injury, because they can cause secondary brain damage through increased metabolic requirements, raised intracranial pressure, cerebral hypoxia, and/or excessive release of neurotransmitters. In children, early PTS are more frequent than late ones. In this retrospective study we conducted an epidemiological analysis and tried to identify potential risk factors for the onset of early PTS in children hospitalized for head injury in our Paediatric Intensive Care Unit. The severity of injury was assessed using the Glasgow Coma Scale (GCS), while the outcome of traumatized children was defined using the Glasgow Outcome Score (GOS). Early PTS were diagnosed in 15 out of the 125 children hospitalized (12%). Most of the children (73.3%), developed seizures within 24 h of the trauma (immediate PTS). Among the risk factors, a very important role was played by the severity of the injury; in fact, the incidence of early PTS among patients with GCS < or = 8 was ten times greater than that among children with GCS 13-15. Other risk factors that significantly influenced the onset of early PTS, were age (60% of children with early PTS were less than 3 years old) and severe cerebral edema. Overall, children with early PTS had a worse outcome than the other patients. In fact, 53% had a GOS of < or = 3 compared to 19.1% of those without early PTS (P |
| doi_str_mv | 10.1007/s003810000368 |
| format | Article |
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In children, early PTS are more frequent than late ones. In this retrospective study we conducted an epidemiological analysis and tried to identify potential risk factors for the onset of early PTS in children hospitalized for head injury in our Paediatric Intensive Care Unit. The severity of injury was assessed using the Glasgow Coma Scale (GCS), while the outcome of traumatized children was defined using the Glasgow Outcome Score (GOS). Early PTS were diagnosed in 15 out of the 125 children hospitalized (12%). Most of the children (73.3%), developed seizures within 24 h of the trauma (immediate PTS). Among the risk factors, a very important role was played by the severity of the injury; in fact, the incidence of early PTS among patients with GCS < or = 8 was ten times greater than that among children with GCS 13-15. Other risk factors that significantly influenced the onset of early PTS, were age (60% of children with early PTS were less than 3 years old) and severe cerebral edema. Overall, children with early PTS had a worse outcome than the other patients. In fact, 53% had a GOS of < or = 3 compared to 19.1% of those without early PTS (P<001). In particular, considering children with severe head injury, 80% of those with early PTS had a GOS of < or = 3, compared to 41% of those without early PTS (P<0.05). In conclusion, PTS can be a serious complication of head injury in children, because they can worsen secondary brain damage. Appropriate management of head-trauma patients must include suitable and immediate prophylaxis with anti-epileptic drugs.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s003810000368</identifier><identifier>PMID: 11156302</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Biological and medical sciences ; Cerebral Hemorrhage - etiology ; Child ; Child, Preschool ; Craniocerebral Trauma - complications ; Craniocerebral Trauma - physiopathology ; Electroencephalography ; Female ; Glasgow Coma Scale ; Humans ; Incidence ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Italy ; Male ; Medical sciences ; Prognosis ; Retrospective Studies ; Risk Factors ; Seizures - diagnosis ; Seizures - epidemiology ; Seizures - etiology ; Seizures - physiopathology ; Time Factors ; Traumas. Diseases due to physical agents</subject><ispartof>Child's nervous system, 2000-12, Vol.16 (12), p.862-866</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c286t-e9ffe1c044d088e6532c88a4dd7df22b2c6209550e4244511e28114af9409ae43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=993267$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11156302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHIARETTI, Antonio</creatorcontrib><creatorcontrib>DE BENEDICTIS, Raffaella</creatorcontrib><creatorcontrib>POLIDORI, Giancarlo</creatorcontrib><creatorcontrib>PIASTRA, Marco</creatorcontrib><creatorcontrib>IANNELLI, Aldo</creatorcontrib><creatorcontrib>DI ROCCO, Concezio</creatorcontrib><title>Early post-traumatic seizures in children with head injury</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><description>Post-traumatic seizures (PTS) can be a serious complication of head injury, because they can cause secondary brain damage through increased metabolic requirements, raised intracranial pressure, cerebral hypoxia, and/or excessive release of neurotransmitters. In children, early PTS are more frequent than late ones. In this retrospective study we conducted an epidemiological analysis and tried to identify potential risk factors for the onset of early PTS in children hospitalized for head injury in our Paediatric Intensive Care Unit. The severity of injury was assessed using the Glasgow Coma Scale (GCS), while the outcome of traumatized children was defined using the Glasgow Outcome Score (GOS). Early PTS were diagnosed in 15 out of the 125 children hospitalized (12%). Most of the children (73.3%), developed seizures within 24 h of the trauma (immediate PTS). Among the risk factors, a very important role was played by the severity of the injury; in fact, the incidence of early PTS among patients with GCS < or = 8 was ten times greater than that among children with GCS 13-15. Other risk factors that significantly influenced the onset of early PTS, were age (60% of children with early PTS were less than 3 years old) and severe cerebral edema. Overall, children with early PTS had a worse outcome than the other patients. In fact, 53% had a GOS of < or = 3 compared to 19.1% of those without early PTS (P<001). In particular, considering children with severe head injury, 80% of those with early PTS had a GOS of < or = 3, compared to 41% of those without early PTS (P<0.05). In conclusion, PTS can be a serious complication of head injury in children, because they can worsen secondary brain damage. Appropriate management of head-trauma patients must include suitable and immediate prophylaxis with anti-epileptic drugs.</description><subject>Biological and medical sciences</subject><subject>Cerebral Hemorrhage - etiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Craniocerebral Trauma - complications</subject><subject>Craniocerebral Trauma - physiopathology</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Glasgow Coma Scale</subject><subject>Humans</subject><subject>Incidence</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Italy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Seizures - diagnosis</subject><subject>Seizures - epidemiology</subject><subject>Seizures - etiology</subject><subject>Seizures - physiopathology</subject><subject>Time Factors</subject><subject>Traumas. Diseases due to physical agents</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0MtLAzEQBvAgiq3Vo1dZ8BydPDfxJqU-oOBFz0uaTGjK9kGyi9S_3pUWxdM3DD8G5iPkmsEdA6jvC4AwwzSENidkzKQQFISCUzIGrjStQcKIXJSyAmDKcHtORowxpQXwMXmYudzuq922dLTLrl-7LvmqYPrqM5YqbSq_TG3IuKk-U7eslujCsF31eX9JzqJrC14dc0I-nmbv0xc6f3t-nT7OqedGdxRtjMg8SBnAGNRKcG-MkyHUIXK-4F5zsEoBSi6lYgy5YUy6aCVYh1JMCD3c9XlbSsbY7HJau7xvGDQ_HTT_Ohj8zcHv-sUaw58-Pj2A2yNwxbs2Zrfxqfw6awXXtfgGI6Vh-w</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>CHIARETTI, Antonio</creator><creator>DE BENEDICTIS, Raffaella</creator><creator>POLIDORI, Giancarlo</creator><creator>PIASTRA, Marco</creator><creator>IANNELLI, Aldo</creator><creator>DI ROCCO, Concezio</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20001201</creationdate><title>Early post-traumatic seizures in children with head injury</title><author>CHIARETTI, Antonio ; DE BENEDICTIS, Raffaella ; POLIDORI, Giancarlo ; PIASTRA, Marco ; IANNELLI, Aldo ; DI ROCCO, Concezio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c286t-e9ffe1c044d088e6532c88a4dd7df22b2c6209550e4244511e28114af9409ae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Cerebral Hemorrhage - etiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Craniocerebral Trauma - complications</topic><topic>Craniocerebral Trauma - physiopathology</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Glasgow Coma Scale</topic><topic>Humans</topic><topic>Incidence</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Italy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Seizures - diagnosis</topic><topic>Seizures - epidemiology</topic><topic>Seizures - etiology</topic><topic>Seizures - physiopathology</topic><topic>Time Factors</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHIARETTI, Antonio</creatorcontrib><creatorcontrib>DE BENEDICTIS, Raffaella</creatorcontrib><creatorcontrib>POLIDORI, Giancarlo</creatorcontrib><creatorcontrib>PIASTRA, Marco</creatorcontrib><creatorcontrib>IANNELLI, Aldo</creatorcontrib><creatorcontrib>DI ROCCO, Concezio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHIARETTI, Antonio</au><au>DE BENEDICTIS, Raffaella</au><au>POLIDORI, Giancarlo</au><au>PIASTRA, Marco</au><au>IANNELLI, Aldo</au><au>DI ROCCO, Concezio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early post-traumatic seizures in children with head injury</atitle><jtitle>Child's nervous system</jtitle><addtitle>Childs Nerv Syst</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>16</volume><issue>12</issue><spage>862</spage><epage>866</epage><pages>862-866</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Post-traumatic seizures (PTS) can be a serious complication of head injury, because they can cause secondary brain damage through increased metabolic requirements, raised intracranial pressure, cerebral hypoxia, and/or excessive release of neurotransmitters. In children, early PTS are more frequent than late ones. In this retrospective study we conducted an epidemiological analysis and tried to identify potential risk factors for the onset of early PTS in children hospitalized for head injury in our Paediatric Intensive Care Unit. The severity of injury was assessed using the Glasgow Coma Scale (GCS), while the outcome of traumatized children was defined using the Glasgow Outcome Score (GOS). Early PTS were diagnosed in 15 out of the 125 children hospitalized (12%). Most of the children (73.3%), developed seizures within 24 h of the trauma (immediate PTS). Among the risk factors, a very important role was played by the severity of the injury; in fact, the incidence of early PTS among patients with GCS < or = 8 was ten times greater than that among children with GCS 13-15. Other risk factors that significantly influenced the onset of early PTS, were age (60% of children with early PTS were less than 3 years old) and severe cerebral edema. Overall, children with early PTS had a worse outcome than the other patients. In fact, 53% had a GOS of < or = 3 compared to 19.1% of those without early PTS (P<001). In particular, considering children with severe head injury, 80% of those with early PTS had a GOS of < or = 3, compared to 41% of those without early PTS (P<0.05). In conclusion, PTS can be a serious complication of head injury in children, because they can worsen secondary brain damage. Appropriate management of head-trauma patients must include suitable and immediate prophylaxis with anti-epileptic drugs.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11156302</pmid><doi>10.1007/s003810000368</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Cerebral Hemorrhage - etiology Child Child, Preschool Craniocerebral Trauma - complications Craniocerebral Trauma - physiopathology Electroencephalography Female Glasgow Coma Scale Humans Incidence Injuries of the nervous system and the skull. Diseases due to physical agents Italy Male Medical sciences Prognosis Retrospective Studies Risk Factors Seizures - diagnosis Seizures - epidemiology Seizures - etiology Seizures - physiopathology Time Factors Traumas. Diseases due to physical agents |
| title | Early post-traumatic seizures in children with head injury |
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