Synergistic interaction between topotecan and microtubule-interfering agents

Topotecan is a topoisomerase I inhibitor with demonstrated anticancer activity in preclinical and clinical studies. The purpose of the present study was to evaluate drug-drug interactions in therapeutic regimens that would combine topotecan with microtubule-interfering agents, such as Taxol and vinb...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2001-09, Vol.48 (3), p.188-196
Hauptverfasser:	BAHADORI, Hamid R, GREEN, Mark R, CATAPANO, Carlo V
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology bcl-X Protein Biological and medical sciences Blotting, Western Cell Cycle - drug effects Chemotherapy Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism DNA Topoisomerases, Type I - metabolism Dose-Response Relationship, Drug Drug Interactions Drug Synergism Enzyme Inhibitors - pharmacology Formazans Humans Medical sciences Microtubules - drug effects Paclitaxel - pharmacology Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - metabolism Tetrazolium Salts Topoisomerase I Inhibitors Topotecan - pharmacology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Vinblastine - pharmacology
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