Characterization of MGI 114 (HMAF) histiospecific toxicity in human tumor cell lines

The acylfulvenes are a class of antitumor agents derived from the fungal toxin illudin S. One acylfulvene derivative, MGI 114 (HMAF), demonstrates marked efficacy in xenograft carcinoma models when compared to the parent acylfulvene or related illudin compounds. The maximum tolerated dose (MTD) of t...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1999, Vol.44 (3), p.235-240
Hauptverfasser:	KELNER, M. J, MCMORRIS, T. C, MONTOYA, M. A, ESTES, L, UGLIK, S. F, RUTHERFORD, M, SAMSON, K. M, BAGNELL, R. D, TAETLE, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biological and medical sciences Chemotherapy DNA, Neoplasm - drug effects Humans Medical sciences Pharmacology. Drug treatments Sesquiterpenes - pharmacokinetics Sesquiterpenes - pharmacology Tumor Cells, Cultured
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