Cellular uptake and antitumor activity of the new anthracycline analog DA-125 in human cancer cell lines

To predict the clinical usefulness of DA-125, a newly developed doxorubicin analog, we compared its antitumor activity against 20 different human cancer cell lines with that of doxorubicin using the MTT in vitro chemosensitivity test. We also measured and compared the cellular uptake of this drug an...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1997, Vol.40 (1), p.23-30
Hauptverfasser:	LIM, K.-H, KIM, H.-S, YANG, Y.-M, LEE, S.-D, KIM, W.-B, YANG, J, PARK, J.-G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Antineoplastic agents ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Biological and medical sciences Chemotherapy Doxorubicin - analogs & derivatives Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Resistance Humans Medical sciences Pharmacology. Drug treatments RNA, Messenger - analysis Tumor Cells, Cultured
Online-Zugang:	Volltext
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