Gastric mucosal blood flow and gastric secretion following intravenous administration of 5-fluorouracil in anesthetized rats

Acute gastric mucosal lesions are often observed after the intravenous administration of high doses of anticancer drugs. To investigate the acute toxic effects of such anticancer therapy on the gastric mucosa, 5-fluorouracil (5-FU) was administered intravenously to anesthetized rats. Gastric mucosal...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1997, Vol.39 (4), p.357-360
Hauptverfasser:	KAKINUMA, S, OHWADA, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Ulcer Agents - pharmacology Antimetabolites, Antineoplastic - adverse effects Biological and medical sciences Drug toxicity and drugs side effects treatment Fluorouracil - adverse effects Gastric Mucosa - blood supply Gastric Mucosa - drug effects Gastric Mucosa - secretion Injections, Intravenous Male Medical sciences Pharmacology. Drug treatments Pirenzepine - pharmacology Rats Regional Blood Flow - drug effects Toxicity: digestive system
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