Clinical Development of Human Polymerized Hemoglobin as a Blood Substitute

Although the efficacy of hemoglobin‐based oxygen carriers was established more than 60 years ago, all prior clinical trials have demonstrated significant toxicity characterized by renal dysfunction, gastrointestinal distress, and systemic vasoconstriction. The mechanisms of these toxicities now appe...

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Veröffentlicht in:	World journal of surgery 1996-11, Vol.20 (9), p.1200-1207
Hauptverfasser:	Gould, Steven A., Moss, Gerald S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Substitute Blood Substitutes - therapeutic use Clinical Trials as Topic Exchange Transfusion, Whole Blood Hemoglobins - therapeutic use Humans Numerous Effort Oxygen Carrier Polymerize Form Pyridoxal Phosphate - analogs & derivatives Pyridoxal Phosphate - therapeutic use Relax Factor Vasoconstriction - physiology
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