Caffeine inhibits a low affinity but not a high affinity mechanism for cholecystokinin-evoked Ca2+ signalling and amylase release from guinea pig pancreatic acini

Caffeine has been found to inhibit the formation and action of Ca2+-mobilizing inositol 1,4,5-trisphosphate (IP3) in pancreatic acinar cells. The aim of the present study was to investigate the effects of caffeine on cytoplasmic Ca2+ concentrations ([Ca2+]i) and amylase release in response to differ...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2000-02, Vol.361 (2), p.113-119
Hauptverfasser:	Sjödin, L, Gylfe, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylases - metabolism Animals Caffeine - pharmacology Calcium Signaling - drug effects Carbachol - pharmacology Dose-Response Relationship, Drug Guinea Pigs Pancreas - drug effects Pancreas - metabolism Sincalide - pharmacology
Online-Zugang:	Volltext
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