Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds

The treatment of poisoning by highly toxic organophosphorus compounds (nerve agents) is unsatisfactory. Until now, the efficacy of new potential antidotes has primarily been evaluated in animals. However, the extrapolation of these results to humans is hampered by species differences. Since oximes a...

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Veröffentlicht in:	Archives of toxicology 1998-03, Vol.72 (4), p.237-243
Hauptverfasser:	WOREK, F, WIDMANN, R, KNOPFF, O, SZINICZ, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Antidotes - metabolism Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cholinesterase Inhibitors - metabolism Cholinesterase Reactivators - metabolism Erythrocytes - enzymology Humans Medical sciences Obidoxime Chloride - metabolism Organophosphates - metabolism Oximes Pralidoxime Compounds - metabolism Pyridines - metabolism Pyridinium Compounds - metabolism Soman - metabolism Toxicology Various organic compounds
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