Total polyphenolic content, antioxidant, cytotoxic, antidiabetic activities, and polyphenolic compounds of Sophora japonica grown in Egypt

The genus Sophora belongs to Fabaceae family, contains about 52 species that are widely distributed in Asia. Several phytochemical, in vivo and in vitro, experiments in addition to clinical practices have demonstrated that Sophora has many phyto-constituents and possesses valuable pharmacological and therapeutic properties. The total polyphenolic’s content, antioxidant, cytotoxic, and antidiabetic activities of Sophora japonica leaves were investigated along with their bio-guided chromatographic isolated polyphenolic constituents. Tested fractions from chromatographic separation of 80 % MeOH extract of S. japonica leaves revealed remarkable antioxidant(s) activity accompanied with some cytotoxic and antidiabetic activities. Moreover, six known polyphenolic constituents isolated from these fractions were identified: tamarixetin, ellagic acid 4-O-α- l -arabinofuranoside, sissotrin, rutin, gallic acid, and quercetin. Graphical Abstract