DNA guanine-guanine crosslinking sequence specificity of isophosphoramide mustard, the alkylating metabolite of the clinical antitumor agent ifosfamide

The purpose of this investigation was to determine the base sequence specificity of isophosphoramide mustard (IPM), the alkylating metabolite of ifosfamide, by crosslinking of designed DNA oligomers in comparison with the clinical alkylating agents mechlorethamine (ME) (nitrogen mustard) and phospho...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2000-01, Vol.45 (1), p.59-62
Hauptverfasser:	STRUCK, R. F, DAVIS, R. L, BERARDINI, M. D, LOECHLER, E. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Alkylating - metabolism Base Sequence Biological and medical sciences Cross-Linking Reagents - metabolism DNA - metabolism General aspects Guanine - metabolism Humans Ifosfamide - metabolism Medical sciences Pharmacology. Drug treatments Phosphoramide Mustards - metabolism
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