Effects of chronic heroin addiction on pituitary-thyroid function in man
Pituitary-thyroid function has been studied in heroin addicts. Data have been obtained in 10 male addicts, aged 18-24 years, with histories of addiction to heroin alone lasting from 8 months to 4 years, and in 9 controls matched for sex and age. Basal plasma levels of TSH, T4 and T3 were measured. A...
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| Veröffentlicht in: | Journal of endocrinological investigation 1980-07, Vol.3 (3), p.251-255 |
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| creator | Brambilla, F Nobile, P Zanoboni, A Zanoboni-Muciaccia, W Meroni, P L |
| description | Pituitary-thyroid function has been studied in heroin addicts. Data have been obtained in 10 male addicts, aged 18-24 years, with histories of addiction to heroin alone lasting from 8 months to 4 years, and in 9 controls matched for sex and age. Basal plasma levels of TSH, T4 and T3 were measured. A TRH stimulation test was done, injecting 500 micrograms of TRH iv as a bolus and assaying TSH levels before the injection and at 30 min intervals up to 2 h afterwards. The results revealed no difference between addicts and controls in basal levels of TSH, T4 and T3. The TRH stimulation test induced a blunted TSH rise in 50% of the cases. The possible mechanism of action of heroin on pituitary-thyroid axis is discussed. |
| doi_str_mv | 10.1007/BF03348271 |
| format | Article |
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Data have been obtained in 10 male addicts, aged 18-24 years, with histories of addiction to heroin alone lasting from 8 months to 4 years, and in 9 controls matched for sex and age. Basal plasma levels of TSH, T4 and T3 were measured. A TRH stimulation test was done, injecting 500 micrograms of TRH iv as a bolus and assaying TSH levels before the injection and at 30 min intervals up to 2 h afterwards. The results revealed no difference between addicts and controls in basal levels of TSH, T4 and T3. The TRH stimulation test induced a blunted TSH rise in 50% of the cases. The possible mechanism of action of heroin on pituitary-thyroid axis is discussed.</description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/BF03348271</identifier><identifier>PMID: 6776179</identifier><language>eng</language><publisher>Italy</publisher><subject>Adolescent ; Adult ; Chronic Disease ; Heroin - pharmacology ; Heroin Dependence - physiopathology ; Humans ; Male ; Pituitary Gland - physiopathology ; Thyroid Gland - physiopathology ; Thyrotropin - blood ; Thyrotropin-Releasing Hormone - blood ; Thyrotropin-Releasing Hormone - pharmacology ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>Journal of endocrinological investigation, 1980-07, Vol.3 (3), p.251-255</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-4d4bb8c0dc2c83798869a3cbec490cd0d45e40771e85a76e49fbe10499d7321d3</citedby><cites>FETCH-LOGICAL-c282t-4d4bb8c0dc2c83798869a3cbec490cd0d45e40771e85a76e49fbe10499d7321d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6776179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brambilla, F</creatorcontrib><creatorcontrib>Nobile, P</creatorcontrib><creatorcontrib>Zanoboni, A</creatorcontrib><creatorcontrib>Zanoboni-Muciaccia, W</creatorcontrib><creatorcontrib>Meroni, P L</creatorcontrib><title>Effects of chronic heroin addiction on pituitary-thyroid function in man</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>Pituitary-thyroid function has been studied in heroin addicts. Data have been obtained in 10 male addicts, aged 18-24 years, with histories of addiction to heroin alone lasting from 8 months to 4 years, and in 9 controls matched for sex and age. Basal plasma levels of TSH, T4 and T3 were measured. A TRH stimulation test was done, injecting 500 micrograms of TRH iv as a bolus and assaying TSH levels before the injection and at 30 min intervals up to 2 h afterwards. The results revealed no difference between addicts and controls in basal levels of TSH, T4 and T3. The TRH stimulation test induced a blunted TSH rise in 50% of the cases. The possible mechanism of action of heroin on pituitary-thyroid axis is discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Chronic Disease</subject><subject>Heroin - pharmacology</subject><subject>Heroin Dependence - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Pituitary Gland - physiopathology</subject><subject>Thyroid Gland - physiopathology</subject><subject>Thyrotropin - blood</subject><subject>Thyrotropin-Releasing Hormone - blood</subject><subject>Thyrotropin-Releasing Hormone - pharmacology</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AUhQdRaqxu3AuzFqJ3Hs2dWWpprVBwo-swmQcZMQ8y6aL_3khKhQtncT4O5x5C7hk8MQB8ft2CEFJxZBckY8ghV0IVlyQDoVkuQeM1uUnpG0CgULggiwKxYKgzstuE4O2YaBeorYeujZbWfuhiS41z0Y6xa-l0fRwPcTTDMR_r42Q7Gg7t7E5oY9pbchXMT_J3J12Sr-3mc73L9x9v7-uXfW654mMunawqZcFZbpVArVShjbCVt1KDdeDkyktAZF6tDBZe6lB5BlJrh4IzJ5bkcc61Q5fS4EPZD7GZipUMyr81yv81JvhhhvtD1Xh3Rk_vi188B1n7</recordid><startdate>198007</startdate><enddate>198007</enddate><creator>Brambilla, F</creator><creator>Nobile, P</creator><creator>Zanoboni, A</creator><creator>Zanoboni-Muciaccia, W</creator><creator>Meroni, P L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198007</creationdate><title>Effects of chronic heroin addiction on pituitary-thyroid function in man</title><author>Brambilla, F ; Nobile, P ; Zanoboni, A ; Zanoboni-Muciaccia, W ; Meroni, P L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-4d4bb8c0dc2c83798869a3cbec490cd0d45e40771e85a76e49fbe10499d7321d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Chronic Disease</topic><topic>Heroin - pharmacology</topic><topic>Heroin Dependence - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Pituitary Gland - physiopathology</topic><topic>Thyroid Gland - physiopathology</topic><topic>Thyrotropin - blood</topic><topic>Thyrotropin-Releasing Hormone - blood</topic><topic>Thyrotropin-Releasing Hormone - pharmacology</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brambilla, F</creatorcontrib><creatorcontrib>Nobile, P</creatorcontrib><creatorcontrib>Zanoboni, A</creatorcontrib><creatorcontrib>Zanoboni-Muciaccia, W</creatorcontrib><creatorcontrib>Meroni, P L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brambilla, F</au><au>Nobile, P</au><au>Zanoboni, A</au><au>Zanoboni-Muciaccia, W</au><au>Meroni, P L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of chronic heroin addiction on pituitary-thyroid function in man</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>1980-07</date><risdate>1980</risdate><volume>3</volume><issue>3</issue><spage>251</spage><epage>255</epage><pages>251-255</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Pituitary-thyroid function has been studied in heroin addicts. 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| ispartof | Journal of endocrinological investigation, 1980-07, Vol.3 (3), p.251-255 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Chronic Disease Heroin - pharmacology Heroin Dependence - physiopathology Humans Male Pituitary Gland - physiopathology Thyroid Gland - physiopathology Thyrotropin - blood Thyrotropin-Releasing Hormone - blood Thyrotropin-Releasing Hormone - pharmacology Thyroxine - blood Triiodothyronine - blood |
| title | Effects of chronic heroin addiction on pituitary-thyroid function in man |
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