Exploratory population pharmacokinetics (e-PPK) analysis for predicting human PK using exploratory ADME data during early drug discovery research

Summary We have proposed a novel method by population pharmacokinetics analysis for forecasting the drug concentration time-course in humans. This method is based on the non-linear mixed effect model (NONMEM) combined with in vitro-in vivo extrapolation (IVIVE). Eleven clinically tested compounds we...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 2009-04, Vol.34 (2), p.117-128
Hauptverfasser:	Tabata, Kenji, Hamakawa, Nozomu, Sanoh, Seigo, Terashita, Shigeyuki, Teramura, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Computer Simulation Dogs Drug Discovery - methods Haplorhini Human Physiology Humans Liver - blood supply Medical Biochemistry Medical sciences Models, Biological Nonlinear Dynamics Pharmaceutical Preparations - metabolism Pharmaceutical Sciences/Technology Pharmacokinetics Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Rats Retrospective Studies Species Specificity Time Factors Tissue Distribution
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