Pharmacokinetics of forsythoside after intravenous administration in beagle dogs
Summary A high-performance liquid chromatography with ultraviolet detection method was established and validated for quantification of forsythoside concentrations in dog plasma. Following a single-step protein precipitation with perchloric acid, the forsythoside and internal standard were separated...
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| Veröffentlicht in: | European journal of drug metabolism and pharmacokinetics 2009-04, Vol.34 (2), p.101-105 |
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| container_title | European journal of drug metabolism and pharmacokinetics |
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| creator | Shi, Rong Xuan, Zhenyu Ma, Yueming Liu, Yingying Lu, Hongguo Sun, Tianjiang |
| description | Summary
A high-performance liquid chromatography with ultraviolet detection method was established and validated for quantification of forsythoside concentrations in dog plasma. Following a single-step protein precipitation with perchloric acid, the forsythoside and internal standard were separated on a reversed-phase C
18
column with water-glacial acetic acid-methanol as mobile phase at a flow rate of 1 mL/min with ultraviolet detection at 326 and 278 nm for forsythoside and IS, respectively. The calibration curve for forsythoside was linear over a range of 0.052–13.33 μg/mL with correlation coefficient of 0.999. The within- and between-batch precisions of analysis were |
| doi_str_mv | 10.1007/BF03191158 |
| format | Article |
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A high-performance liquid chromatography with ultraviolet detection method was established and validated for quantification of forsythoside concentrations in dog plasma. Following a single-step protein precipitation with perchloric acid, the forsythoside and internal standard were separated on a reversed-phase C
18
column with water-glacial acetic acid-methanol as mobile phase at a flow rate of 1 mL/min with ultraviolet detection at 326 and 278 nm for forsythoside and IS, respectively. The calibration curve for forsythoside was linear over a range of 0.052–13.33 μg/mL with correlation coefficient of 0.999. The within- and between-batch precisions of analysis were <8 % and accuracy was 95–107%. After intravenous administration of forsythoside at the doses of 5, 10, and 20 mg/kg, the
C
max
values for forsythoside were estimated to be of 12.33, 22.90 and 54.45 μg/mL, respectively. The AUC increased with the increasing of doses, and the mean AUC
0-t
values were 5.69, 11.80, and 18.66 mg·h/L, respectively. Forsythoside was eliminated quickly and the mean
T
m
values at doses of 5, 10, and 20 mg/kg were 1.36, 1.49, and 0.71h, respectively. The pharmacokinetics of forsythoside in beagle dogs complied with linear kinetic course in the dose range.</description><identifier>ISSN: 0378-7966</identifier><identifier>EISSN: 2107-0180</identifier><identifier>DOI: 10.1007/BF03191158</identifier><identifier>PMID: 19645219</identifier><language>eng</language><publisher>Paris: Springer-Verlag</publisher><subject>Animals ; Area Under Curve ; Biomedical and Life Sciences ; Biomedicine ; Chromatography, High Pressure Liquid - methods ; Dogs ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - pharmacokinetics ; Female ; Forsythia - chemistry ; Glycosides - administration & dosage ; Glycosides - pharmacokinetics ; Half-Life ; Human Physiology ; Injections, Intravenous ; Male ; Medical Biochemistry ; Pharmaceutical Sciences/Technology ; Pharmacology/Toxicology ; Pharmacy ; Reproducibility of Results</subject><ispartof>European journal of drug metabolism and pharmacokinetics, 2009-04, Vol.34 (2), p.101-105</ispartof><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-8db789e28d64137e97d664f458a5cd6dd6ffccc282afbd3a96344dfdb3aa0e373</citedby><cites>FETCH-LOGICAL-c321t-8db789e28d64137e97d664f458a5cd6dd6ffccc282afbd3a96344dfdb3aa0e373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/BF03191158$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/BF03191158$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19645219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Rong</creatorcontrib><creatorcontrib>Xuan, Zhenyu</creatorcontrib><creatorcontrib>Ma, Yueming</creatorcontrib><creatorcontrib>Liu, Yingying</creatorcontrib><creatorcontrib>Lu, Hongguo</creatorcontrib><creatorcontrib>Sun, Tianjiang</creatorcontrib><title>Pharmacokinetics of forsythoside after intravenous administration in beagle dogs</title><title>European journal of drug metabolism and pharmacokinetics</title><addtitle>Eur. J. Drug Metabol. Pharmacokinet</addtitle><addtitle>Eur J Drug Metab Pharmacokinet</addtitle><description>Summary
A high-performance liquid chromatography with ultraviolet detection method was established and validated for quantification of forsythoside concentrations in dog plasma. Following a single-step protein precipitation with perchloric acid, the forsythoside and internal standard were separated on a reversed-phase C
18
column with water-glacial acetic acid-methanol as mobile phase at a flow rate of 1 mL/min with ultraviolet detection at 326 and 278 nm for forsythoside and IS, respectively. The calibration curve for forsythoside was linear over a range of 0.052–13.33 μg/mL with correlation coefficient of 0.999. The within- and between-batch precisions of analysis were <8 % and accuracy was 95–107%. After intravenous administration of forsythoside at the doses of 5, 10, and 20 mg/kg, the
C
max
values for forsythoside were estimated to be of 12.33, 22.90 and 54.45 μg/mL, respectively. The AUC increased with the increasing of doses, and the mean AUC
0-t
values were 5.69, 11.80, and 18.66 mg·h/L, respectively. Forsythoside was eliminated quickly and the mean
T
m
values at doses of 5, 10, and 20 mg/kg were 1.36, 1.49, and 0.71h, respectively. The pharmacokinetics of forsythoside in beagle dogs complied with linear kinetic course in the dose range.</description><subject>Animals</subject><subject>Area Under Curve</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - pharmacokinetics</subject><subject>Female</subject><subject>Forsythia - chemistry</subject><subject>Glycosides - administration & dosage</subject><subject>Glycosides - pharmacokinetics</subject><subject>Half-Life</subject><subject>Human Physiology</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical Biochemistry</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Reproducibility of Results</subject><issn>0378-7966</issn><issn>2107-0180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LAzEURYMottRu_AGStTKaTGbysdTSqlCwC10PmXy0qZ2kJDNC_72RFrrxbR68e7jwDgC3GD1ihNjTywIRLDCu-QUYlxixAmGOLsEYEcYLJigdgWlKW5SHcFHX9BqMsKBVXWIxBqvVRsZOqvDtvOmdSjBYaENMh34TktMGStubCJ3vo_wxPgwJSt0571I-9C74HMHWyPXOQB3W6QZcWblLZnraE_C1mH_O3orlx-v77HlZKFLivuC6ZVyYkmtaYcKMYJrSylY1l7XSVGtqrVKq5KW0rSZSUFJV2uqWSIkMYWQC7o-9KoaUorHNPrpOxkODUfNnpjmbyfDdEd4PbWf0GT15yMDDEUg58msTm20Yos8P_Ff3C5__bVw</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Shi, Rong</creator><creator>Xuan, Zhenyu</creator><creator>Ma, Yueming</creator><creator>Liu, Yingying</creator><creator>Lu, Hongguo</creator><creator>Sun, Tianjiang</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20090401</creationdate><title>Pharmacokinetics of forsythoside after intravenous administration in beagle dogs</title><author>Shi, Rong ; Xuan, Zhenyu ; Ma, Yueming ; Liu, Yingying ; Lu, Hongguo ; Sun, Tianjiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-8db789e28d64137e97d664f458a5cd6dd6ffccc282afbd3a96344dfdb3aa0e373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Area Under Curve</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - pharmacokinetics</topic><topic>Female</topic><topic>Forsythia - chemistry</topic><topic>Glycosides - administration & dosage</topic><topic>Glycosides - pharmacokinetics</topic><topic>Half-Life</topic><topic>Human Physiology</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical Biochemistry</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Rong</creatorcontrib><creatorcontrib>Xuan, Zhenyu</creatorcontrib><creatorcontrib>Ma, Yueming</creatorcontrib><creatorcontrib>Liu, Yingying</creatorcontrib><creatorcontrib>Lu, Hongguo</creatorcontrib><creatorcontrib>Sun, Tianjiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of drug metabolism and pharmacokinetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Rong</au><au>Xuan, Zhenyu</au><au>Ma, Yueming</au><au>Liu, Yingying</au><au>Lu, Hongguo</au><au>Sun, Tianjiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of forsythoside after intravenous administration in beagle dogs</atitle><jtitle>European journal of drug metabolism and pharmacokinetics</jtitle><stitle>Eur. J. Drug Metabol. Pharmacokinet</stitle><addtitle>Eur J Drug Metab Pharmacokinet</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>34</volume><issue>2</issue><spage>101</spage><epage>105</epage><pages>101-105</pages><issn>0378-7966</issn><eissn>2107-0180</eissn><abstract>Summary
A high-performance liquid chromatography with ultraviolet detection method was established and validated for quantification of forsythoside concentrations in dog plasma. Following a single-step protein precipitation with perchloric acid, the forsythoside and internal standard were separated on a reversed-phase C
18
column with water-glacial acetic acid-methanol as mobile phase at a flow rate of 1 mL/min with ultraviolet detection at 326 and 278 nm for forsythoside and IS, respectively. The calibration curve for forsythoside was linear over a range of 0.052–13.33 μg/mL with correlation coefficient of 0.999. The within- and between-batch precisions of analysis were <8 % and accuracy was 95–107%. After intravenous administration of forsythoside at the doses of 5, 10, and 20 mg/kg, the
C
max
values for forsythoside were estimated to be of 12.33, 22.90 and 54.45 μg/mL, respectively. The AUC increased with the increasing of doses, and the mean AUC
0-t
values were 5.69, 11.80, and 18.66 mg·h/L, respectively. Forsythoside was eliminated quickly and the mean
T
m
values at doses of 5, 10, and 20 mg/kg were 1.36, 1.49, and 0.71h, respectively. The pharmacokinetics of forsythoside in beagle dogs complied with linear kinetic course in the dose range.</abstract><cop>Paris</cop><pub>Springer-Verlag</pub><pmid>19645219</pmid><doi>10.1007/BF03191158</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Area Under Curve Biomedical and Life Sciences Biomedicine Chromatography, High Pressure Liquid - methods Dogs Dose-Response Relationship, Drug Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacokinetics Female Forsythia - chemistry Glycosides - administration & dosage Glycosides - pharmacokinetics Half-Life Human Physiology Injections, Intravenous Male Medical Biochemistry Pharmaceutical Sciences/Technology Pharmacology/Toxicology Pharmacy Reproducibility of Results |
| title | Pharmacokinetics of forsythoside after intravenous administration in beagle dogs |
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