Assessment of pharmacokinetic interaction between theophylline and loperamide in the rat

The effect of loparamide (1 mgkg-1, p.o.) on the pharma-cokinetics of theophylline was studied in the rat. Theophylline (as aminophylline-25 mgkg-1, p.o.) was administered either alone, in combination with, or 1 hr after loperamide. Plasma levels of theophylline were serially measured over a period...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 1989-10, Vol.14 (4), p.283-286
Hauptverfasser:	Tekle, A, Bawazir, S A, al-Hassan, M I, Matar, K M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Proteins - metabolism Chromatography, High Pressure Liquid Drug Interactions Loperamide - pharmacology Male Piperidines - pharmacology Protein Binding Rats Rats, Inbred Strains Theophylline - blood Theophylline - pharmacokinetics
Online-Zugang:	Volltext
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