Tussive effect of a fentanyl bolus
The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl. The study sample was 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. The first 100 were randomly allocated to receive 1.5 micrograms.kg-1 fentan...
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Veröffentlicht in: | Canadian journal of anesthesia 1991-04, Vol.38 (3), p.330-334 |
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description | The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl. The study sample was 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. The first 100 were randomly allocated to receive 1.5 micrograms.kg-1 fentanyl via a peripheral venous cannula (Group 1), or an equivalent volume of saline (Group 2). Twenty-eight per cent of patients who received fentanyl, but none given saline, coughed within one minute (P less than 0.0001). The second 150 patients were then randomly assigned to three equal pretreatment groups. Group 3 received 0.01 mg.kg-1 atropine iv one minute before fentanyl. Groups 4 and 5 received 0.2 mg.kg-1 morphine im, and 7.5 mg midazolam po, respectively, one hour before fentanyl. Thirty per cent of patients in Group 3, 6% in Group 4, and 40% in Group 5, had a cough response to fentanyl. Fentanyl, when given through a peripheral cannula, provoked cough in a considerable proportion of patients. This was not altered by premedication with atropine or midazolam, but was reduced after morphine (P less than 0.01). Coughing upon induction of anaesthesia is undesirable in some patients, and stimulation of cough by fentanyl in unpremedicated patients may be of clinical importance. |
doi_str_mv | 10.1007/BF03007623 |
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A</creator><creatorcontrib>WEE THUAN PHUA ; BOON TECK TEH ; JONG, W ; TAT LEANG LEE ; TWEED, W. A</creatorcontrib><description>The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl. The study sample was 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. The first 100 were randomly allocated to receive 1.5 micrograms.kg-1 fentanyl via a peripheral venous cannula (Group 1), or an equivalent volume of saline (Group 2). Twenty-eight per cent of patients who received fentanyl, but none given saline, coughed within one minute (P less than 0.0001). The second 150 patients were then randomly assigned to three equal pretreatment groups. Group 3 received 0.01 mg.kg-1 atropine iv one minute before fentanyl. Groups 4 and 5 received 0.2 mg.kg-1 morphine im, and 7.5 mg midazolam po, respectively, one hour before fentanyl. Thirty per cent of patients in Group 3, 6% in Group 4, and 40% in Group 5, had a cough response to fentanyl. Fentanyl, when given through a peripheral cannula, provoked cough in a considerable proportion of patients. This was not altered by premedication with atropine or midazolam, but was reduced after morphine (P less than 0.01). Coughing upon induction of anaesthesia is undesirable in some patients, and stimulation of cough by fentanyl in unpremedicated patients may be of clinical importance.</description><identifier>ISSN: 0832-610X</identifier><identifier>EISSN: 1496-8975</identifier><identifier>DOI: 10.1007/BF03007623</identifier><identifier>PMID: 2036693</identifier><identifier>CODEN: CJOAEP</identifier><language>eng</language><publisher>Toronto, ON: Canadian Anesthesiologists' Society</publisher><subject>Adult ; Analysis of Variance ; Anesthesia, Intravenous ; Atropine - administration & dosage ; Atropine - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; Cough - chemically induced ; Cough - epidemiology ; Double-Blind Method ; Drug toxicity and drugs side effects treatment ; Fentanyl - administration & dosage ; Fentanyl - adverse effects ; Heart Rate - drug effects ; Humans ; Incidence ; Medical sciences ; Midazolam - administration & dosage ; Midazolam - pharmacology ; Morphine - administration & dosage ; Morphine - pharmacology ; Oxygen Consumption - drug effects ; Pharmacology. Drug treatments ; Preanesthetic Medication ; Prospective Studies ; Reflex - drug effects ; Reflex - physiology ; Singapore - epidemiology ; Toxicity: respiratory system, ent, stomatology</subject><ispartof>Canadian journal of anesthesia, 1991-04, Vol.38 (3), p.330-334</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-7d6c73fca0acfead7269353e4a1d848a9c1f709e605563565c2474a35137a0c63</citedby><cites>FETCH-LOGICAL-c348t-7d6c73fca0acfead7269353e4a1d848a9c1f709e605563565c2474a35137a0c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19666541$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2036693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WEE THUAN PHUA</creatorcontrib><creatorcontrib>BOON TECK TEH</creatorcontrib><creatorcontrib>JONG, W</creatorcontrib><creatorcontrib>TAT LEANG LEE</creatorcontrib><creatorcontrib>TWEED, W. A</creatorcontrib><title>Tussive effect of a fentanyl bolus</title><title>Canadian journal of anesthesia</title><addtitle>Can J Anaesth</addtitle><description>The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl. The study sample was 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. The first 100 were randomly allocated to receive 1.5 micrograms.kg-1 fentanyl via a peripheral venous cannula (Group 1), or an equivalent volume of saline (Group 2). Twenty-eight per cent of patients who received fentanyl, but none given saline, coughed within one minute (P less than 0.0001). The second 150 patients were then randomly assigned to three equal pretreatment groups. Group 3 received 0.01 mg.kg-1 atropine iv one minute before fentanyl. Groups 4 and 5 received 0.2 mg.kg-1 morphine im, and 7.5 mg midazolam po, respectively, one hour before fentanyl. Thirty per cent of patients in Group 3, 6% in Group 4, and 40% in Group 5, had a cough response to fentanyl. Fentanyl, when given through a peripheral cannula, provoked cough in a considerable proportion of patients. This was not altered by premedication with atropine or midazolam, but was reduced after morphine (P less than 0.01). Coughing upon induction of anaesthesia is undesirable in some patients, and stimulation of cough by fentanyl in unpremedicated patients may be of clinical importance.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Anesthesia, Intravenous</subject><subject>Atropine - administration & dosage</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cough - chemically induced</subject><subject>Cough - epidemiology</subject><subject>Double-Blind Method</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Fentanyl - administration & dosage</subject><subject>Fentanyl - adverse effects</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Medical sciences</subject><subject>Midazolam - administration & dosage</subject><subject>Midazolam - pharmacology</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - pharmacology</subject><subject>Oxygen Consumption - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Preanesthetic Medication</subject><subject>Prospective Studies</subject><subject>Reflex - drug effects</subject><subject>Reflex - physiology</subject><subject>Singapore - epidemiology</subject><subject>Toxicity: respiratory system, ent, stomatology</subject><issn>0832-610X</issn><issn>1496-8975</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj0FLw0AQhRdRaqxevAtB8CJEZzO7s5ujFqtCwUsFb2G62YVI2pRsIvTfG2mxp3d4H-_xCXEt4UECmMfnOeCYlOOJSKQqKLOF0aciAYt5RhK-zsVFjN8AYEnbiZjkgEQFJuJ2OcRY__jUh-Bdn7Yh5TT4Tc-bXZOu2maIl-IscBP91SGn4nP-spy9ZYuP1_fZ0yJzqGyfmYqcweAY2AXPlcnHA41esaysslw4GQwUnkBrQk3a5cooRi3RMDjCqbjf77qujbHzodx29Zq7XSmh_PMsj54jfLOHt8Nq7at_9CA29neHnqPjJnS8cXU8LhZEpJXEX7ilV54</recordid><startdate>19910401</startdate><enddate>19910401</enddate><creator>WEE THUAN PHUA</creator><creator>BOON TECK TEH</creator><creator>JONG, W</creator><creator>TAT LEANG LEE</creator><creator>TWEED, W. A</creator><general>Canadian Anesthesiologists' Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19910401</creationdate><title>Tussive effect of a fentanyl bolus</title><author>WEE THUAN PHUA ; BOON TECK TEH ; JONG, W ; TAT LEANG LEE ; TWEED, W. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-7d6c73fca0acfead7269353e4a1d848a9c1f709e605563565c2474a35137a0c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Anesthesia, Intravenous</topic><topic>Atropine - administration & dosage</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cough - chemically induced</topic><topic>Cough - epidemiology</topic><topic>Double-Blind Method</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Fentanyl - administration & dosage</topic><topic>Fentanyl - adverse effects</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Medical sciences</topic><topic>Midazolam - administration & dosage</topic><topic>Midazolam - pharmacology</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - pharmacology</topic><topic>Oxygen Consumption - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Preanesthetic Medication</topic><topic>Prospective Studies</topic><topic>Reflex - drug effects</topic><topic>Reflex - physiology</topic><topic>Singapore - epidemiology</topic><topic>Toxicity: respiratory system, ent, stomatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEE THUAN PHUA</creatorcontrib><creatorcontrib>BOON TECK TEH</creatorcontrib><creatorcontrib>JONG, W</creatorcontrib><creatorcontrib>TAT LEANG LEE</creatorcontrib><creatorcontrib>TWEED, W. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tussive effect of a fentanyl bolus</atitle><jtitle>Canadian journal of anesthesia</jtitle><addtitle>Can J Anaesth</addtitle><date>1991-04-01</date><risdate>1991</risdate><volume>38</volume><issue>3</issue><spage>330</spage><epage>334</epage><pages>330-334</pages><issn>0832-610X</issn><eissn>1496-8975</eissn><coden>CJOAEP</coden><abstract>The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl. The study sample was 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. The first 100 were randomly allocated to receive 1.5 micrograms.kg-1 fentanyl via a peripheral venous cannula (Group 1), or an equivalent volume of saline (Group 2). Twenty-eight per cent of patients who received fentanyl, but none given saline, coughed within one minute (P less than 0.0001). The second 150 patients were then randomly assigned to three equal pretreatment groups. Group 3 received 0.01 mg.kg-1 atropine iv one minute before fentanyl. Groups 4 and 5 received 0.2 mg.kg-1 morphine im, and 7.5 mg midazolam po, respectively, one hour before fentanyl. Thirty per cent of patients in Group 3, 6% in Group 4, and 40% in Group 5, had a cough response to fentanyl. Fentanyl, when given through a peripheral cannula, provoked cough in a considerable proportion of patients. This was not altered by premedication with atropine or midazolam, but was reduced after morphine (P less than 0.01). Coughing upon induction of anaesthesia is undesirable in some patients, and stimulation of cough by fentanyl in unpremedicated patients may be of clinical importance.</abstract><cop>Toronto, ON</cop><pub>Canadian Anesthesiologists' Society</pub><pmid>2036693</pmid><doi>10.1007/BF03007623</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Analysis of Variance Anesthesia, Intravenous Atropine - administration & dosage Atropine - pharmacology Biological and medical sciences Blood Pressure - drug effects Cough - chemically induced Cough - epidemiology Double-Blind Method Drug toxicity and drugs side effects treatment Fentanyl - administration & dosage Fentanyl - adverse effects Heart Rate - drug effects Humans Incidence Medical sciences Midazolam - administration & dosage Midazolam - pharmacology Morphine - administration & dosage Morphine - pharmacology Oxygen Consumption - drug effects Pharmacology. Drug treatments Preanesthetic Medication Prospective Studies Reflex - drug effects Reflex - physiology Singapore - epidemiology Toxicity: respiratory system, ent, stomatology |
title | Tussive effect of a fentanyl bolus |
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