Tussive effect of a fentanyl bolus

The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl. The study sample was 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. The first 100 were randomly allocated to receive 1.5 micrograms.kg-1 fentan...

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Veröffentlicht in:Canadian journal of anesthesia 1991-04, Vol.38 (3), p.330-334
Hauptverfasser: WEE THUAN PHUA, BOON TECK TEH, JONG, W, TAT LEANG LEE, TWEED, W. A
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container_end_page 334
container_issue 3
container_start_page 330
container_title Canadian journal of anesthesia
container_volume 38
creator WEE THUAN PHUA
BOON TECK TEH
JONG, W
TAT LEANG LEE
TWEED, W. A
description The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl. The study sample was 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. The first 100 were randomly allocated to receive 1.5 micrograms.kg-1 fentanyl via a peripheral venous cannula (Group 1), or an equivalent volume of saline (Group 2). Twenty-eight per cent of patients who received fentanyl, but none given saline, coughed within one minute (P less than 0.0001). The second 150 patients were then randomly assigned to three equal pretreatment groups. Group 3 received 0.01 mg.kg-1 atropine iv one minute before fentanyl. Groups 4 and 5 received 0.2 mg.kg-1 morphine im, and 7.5 mg midazolam po, respectively, one hour before fentanyl. Thirty per cent of patients in Group 3, 6% in Group 4, and 40% in Group 5, had a cough response to fentanyl. Fentanyl, when given through a peripheral cannula, provoked cough in a considerable proportion of patients. This was not altered by premedication with atropine or midazolam, but was reduced after morphine (P less than 0.01). Coughing upon induction of anaesthesia is undesirable in some patients, and stimulation of cough by fentanyl in unpremedicated patients may be of clinical importance.
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Coughing upon induction of anaesthesia is undesirable in some patients, and stimulation of cough by fentanyl in unpremedicated patients may be of clinical importance.</description><identifier>ISSN: 0832-610X</identifier><identifier>EISSN: 1496-8975</identifier><identifier>DOI: 10.1007/BF03007623</identifier><identifier>PMID: 2036693</identifier><identifier>CODEN: CJOAEP</identifier><language>eng</language><publisher>Toronto, ON: Canadian Anesthesiologists' Society</publisher><subject>Adult ; Analysis of Variance ; Anesthesia, Intravenous ; Atropine - administration &amp; dosage ; Atropine - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; Cough - chemically induced ; Cough - epidemiology ; Double-Blind Method ; Drug toxicity and drugs side effects treatment ; Fentanyl - administration &amp; dosage ; Fentanyl - adverse effects ; Heart Rate - drug effects ; Humans ; Incidence ; Medical sciences ; Midazolam - administration &amp; dosage ; Midazolam - pharmacology ; Morphine - administration &amp; dosage ; Morphine - pharmacology ; Oxygen Consumption - drug effects ; Pharmacology. 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A</creatorcontrib><title>Tussive effect of a fentanyl bolus</title><title>Canadian journal of anesthesia</title><addtitle>Can J Anaesth</addtitle><description>The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl. The study sample was 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. The first 100 were randomly allocated to receive 1.5 micrograms.kg-1 fentanyl via a peripheral venous cannula (Group 1), or an equivalent volume of saline (Group 2). Twenty-eight per cent of patients who received fentanyl, but none given saline, coughed within one minute (P less than 0.0001). The second 150 patients were then randomly assigned to three equal pretreatment groups. Group 3 received 0.01 mg.kg-1 atropine iv one minute before fentanyl. Groups 4 and 5 received 0.2 mg.kg-1 morphine im, and 7.5 mg midazolam po, respectively, one hour before fentanyl. 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Coughing upon induction of anaesthesia is undesirable in some patients, and stimulation of cough by fentanyl in unpremedicated patients may be of clinical importance.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Anesthesia, Intravenous</subject><subject>Atropine - administration &amp; dosage</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cough - chemically induced</subject><subject>Cough - epidemiology</subject><subject>Double-Blind Method</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Fentanyl - administration &amp; dosage</subject><subject>Fentanyl - adverse effects</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Medical sciences</subject><subject>Midazolam - administration &amp; dosage</subject><subject>Midazolam - pharmacology</subject><subject>Morphine - administration &amp; dosage</subject><subject>Morphine - pharmacology</subject><subject>Oxygen Consumption - drug effects</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Preanesthetic Medication</topic><topic>Prospective Studies</topic><topic>Reflex - drug effects</topic><topic>Reflex - physiology</topic><topic>Singapore - epidemiology</topic><topic>Toxicity: respiratory system, ent, stomatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEE THUAN PHUA</creatorcontrib><creatorcontrib>BOON TECK TEH</creatorcontrib><creatorcontrib>JONG, W</creatorcontrib><creatorcontrib>TAT LEANG LEE</creatorcontrib><creatorcontrib>TWEED, W. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tussive effect of a fentanyl bolus</atitle><jtitle>Canadian journal of anesthesia</jtitle><addtitle>Can J Anaesth</addtitle><date>1991-04-01</date><risdate>1991</risdate><volume>38</volume><issue>3</issue><spage>330</spage><epage>334</epage><pages>330-334</pages><issn>0832-610X</issn><eissn>1496-8975</eissn><coden>CJOAEP</coden><abstract>The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl. The study sample was 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. The first 100 were randomly allocated to receive 1.5 micrograms.kg-1 fentanyl via a peripheral venous cannula (Group 1), or an equivalent volume of saline (Group 2). Twenty-eight per cent of patients who received fentanyl, but none given saline, coughed within one minute (P less than 0.0001). 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identifier ISSN: 0832-610X
ispartof Canadian journal of anesthesia, 1991-04, Vol.38 (3), p.330-334
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source MEDLINE; SpringerNature Journals
subjects Adult
Analysis of Variance
Anesthesia, Intravenous
Atropine - administration & dosage
Atropine - pharmacology
Biological and medical sciences
Blood Pressure - drug effects
Cough - chemically induced
Cough - epidemiology
Double-Blind Method
Drug toxicity and drugs side effects treatment
Fentanyl - administration & dosage
Fentanyl - adverse effects
Heart Rate - drug effects
Humans
Incidence
Medical sciences
Midazolam - administration & dosage
Midazolam - pharmacology
Morphine - administration & dosage
Morphine - pharmacology
Oxygen Consumption - drug effects
Pharmacology. Drug treatments
Preanesthetic Medication
Prospective Studies
Reflex - drug effects
Reflex - physiology
Singapore - epidemiology
Toxicity: respiratory system, ent, stomatology
title Tussive effect of a fentanyl bolus
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