Propranolol pretreatment reduces cardiorespiratory toxicity due to plain, but not epinephrine-containing, intravenous bupivacaine in rats

The purpose of this study was to evaluate the effects of pretreatment with propranolol on the cardio-respiratory toxicity of bupivacaine, either plain or with epinephrine 1:200,000 (5 micrograms.ml-1) added. Adult male Sprague Dawley rats, anaesthetized with intraperitoneal pentobarbital, were divid...

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Veröffentlicht in:	Canadian journal of anesthesia 1991-05, Vol.38 (4), p.533-536
Hauptverfasser:	KINNEY, W. W, KAMBAM, J. R, WRIGHT, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apnea - chemically induced Arrhythmias, Cardiac - chemically induced Biological and medical sciences Bupivacaine - administration & dosage Bupivacaine - toxicity Drug toxicity and drugs side effects treatment Electrocardiography - drug effects Epinephrine - administration & dosage Epinephrine - pharmacology Heart - drug effects Injections, Intravenous Lung - drug effects Male Medical sciences Pharmacology. Drug treatments Preanesthetic Medication Propranolol - administration & dosage Propranolol - pharmacology Rats Rats, Inbred Strains Toxicity: cardiovascular system
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