In vitro anticomplementary activity of hederagenin saponins isolated from roots ofDipsacus asper
Anticomplementary activity of hederagenin and related saponins isolated fromDipsacus asper was investigatedin vitro. HN saponin F (3) was most potent with IC₅₀ value of 3.7×10⁻⁵ M followed by 3-O-β-D-glucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyrano...
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| Veröffentlicht in: | Archives of pharmacal research 1999-06, Vol.22 (3), p.317-319 |
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| container_title | Archives of pharmacal research |
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| creator | Oh, Sei -Ryang Jung, Keun Young Son, Kun Ho Park, Si Hyung Lee, Im Seon Ahn, Kyung Seop Lee, Hyeong-Kyu |
| description | Anticomplementary activity of hederagenin and related saponins isolated fromDipsacus asper was investigatedin vitro. HN saponin F (3) was most potent with IC₅₀ value of 3.7×10⁻⁵ M followed by 3-O-β-D-glucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyrano side (8), 3-O-β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyrano side (5) dipsacus saponin A (4), and hederagenin (1) on the classical pathway (CP) of complement system, while the saponins3–5, did not show the inhibition of hemolysis and rather increase the hemolysis on the alternative pathway (AP). However, all of C-3 monodesmosides [prosapogenin CP (2), dipsacus saponin B (6), and dipsacus saponin C (7)] evoked hemolysis directly on the erythrocytes. |
| doi_str_mv | 10.1007/bf02976371 |
| format | Article |
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HN saponin F (3) was most potent with IC₅₀ value of 3.7×10⁻⁵ M followed by 3-O-β-D-glucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyrano side (8), 3-O-β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyrano side (5) dipsacus saponin A (4), and hederagenin (1) on the classical pathway (CP) of complement system, while the saponins3–5, did not show the inhibition of hemolysis and rather increase the hemolysis on the alternative pathway (AP). However, all of C-3 monodesmosides [prosapogenin CP (2), dipsacus saponin B (6), and dipsacus saponin C (7)] evoked hemolysis directly on the erythrocytes.</description><identifier>ISSN: 0253-6269</identifier><identifier>EISSN: 1976-3786</identifier><identifier>DOI: 10.1007/bf02976371</identifier><language>eng</language><publisher>Pharmaceutical Society of Korea</publisher><subject>complement ; desmosides ; erythrocytes ; hemolysis ; inhibitory concentration 50 ; roots</subject><ispartof>Archives of pharmacal research, 1999-06, Vol.22 (3), p.317-319</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1660-367db7c4f41e4063b2267115c312cf4aad58d927b3304f45fbd0206a2bf3d3053</citedby><cites>FETCH-LOGICAL-c1660-367db7c4f41e4063b2267115c312cf4aad58d927b3304f45fbd0206a2bf3d3053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Oh, Sei -Ryang</creatorcontrib><creatorcontrib>Jung, Keun Young</creatorcontrib><creatorcontrib>Son, Kun Ho</creatorcontrib><creatorcontrib>Park, Si Hyung</creatorcontrib><creatorcontrib>Lee, Im Seon</creatorcontrib><creatorcontrib>Ahn, Kyung Seop</creatorcontrib><creatorcontrib>Lee, Hyeong-Kyu</creatorcontrib><title>In vitro anticomplementary activity of hederagenin saponins isolated from roots ofDipsacus asper</title><title>Archives of pharmacal research</title><description>Anticomplementary activity of hederagenin and related saponins isolated fromDipsacus asper was investigatedin vitro. 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However, all of C-3 monodesmosides [prosapogenin CP (2), dipsacus saponin B (6), and dipsacus saponin C (7)] evoked hemolysis directly on the erythrocytes.</description><subject>complement</subject><subject>desmosides</subject><subject>erythrocytes</subject><subject>hemolysis</subject><subject>inhibitory concentration 50</subject><subject>roots</subject><issn>0253-6269</issn><issn>1976-3786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNo1kEFLxDAUhIMoWFcv_gFzFqovSZNsj7q6urDgQfdcX9NkjWybklRh_72R1dMMvI8Z3hByyeCGAejb1gGvtRKaHZGCZVcKPVfHpAAuRam4qk_JWUqfAEJJKQvyvhrot59ioDhM3oR-3NneDhPGPUUz-Xzb0-Doh-1sxK0d_EATjiFroj6FHU62oy6GnsYQppTZBz8mNF-JYhptPCcnDnfJXvzpjGyWj2-L53L98rRa3K1Lw5SCUijdtdpUrmK2AiVazpVmTBrBuHEVYifnXc11KwRkSLq2Aw4KeetEJ0CKGbk-5JoYUorWNWP0fX6jYdD8btPcL_-3yfDVAXYYGtxGn5rNKwemAIDVuUH8ABpDYSg</recordid><startdate>199906</startdate><enddate>199906</enddate><creator>Oh, Sei -Ryang</creator><creator>Jung, Keun Young</creator><creator>Son, Kun Ho</creator><creator>Park, Si Hyung</creator><creator>Lee, Im Seon</creator><creator>Ahn, Kyung Seop</creator><creator>Lee, Hyeong-Kyu</creator><general>Pharmaceutical Society of Korea</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199906</creationdate><title>In vitro anticomplementary activity of hederagenin saponins isolated from roots ofDipsacus asper</title><author>Oh, Sei -Ryang ; Jung, Keun Young ; Son, Kun Ho ; Park, Si Hyung ; Lee, Im Seon ; Ahn, Kyung Seop ; Lee, Hyeong-Kyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1660-367db7c4f41e4063b2267115c312cf4aad58d927b3304f45fbd0206a2bf3d3053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>complement</topic><topic>desmosides</topic><topic>erythrocytes</topic><topic>hemolysis</topic><topic>inhibitory concentration 50</topic><topic>roots</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Sei -Ryang</creatorcontrib><creatorcontrib>Jung, Keun Young</creatorcontrib><creatorcontrib>Son, Kun Ho</creatorcontrib><creatorcontrib>Park, Si Hyung</creatorcontrib><creatorcontrib>Lee, Im Seon</creatorcontrib><creatorcontrib>Ahn, Kyung Seop</creatorcontrib><creatorcontrib>Lee, Hyeong-Kyu</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><jtitle>Archives of pharmacal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Sei -Ryang</au><au>Jung, Keun Young</au><au>Son, Kun Ho</au><au>Park, Si Hyung</au><au>Lee, Im Seon</au><au>Ahn, Kyung Seop</au><au>Lee, Hyeong-Kyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro anticomplementary activity of hederagenin saponins isolated from roots ofDipsacus asper</atitle><jtitle>Archives of pharmacal research</jtitle><date>1999-06</date><risdate>1999</risdate><volume>22</volume><issue>3</issue><spage>317</spage><epage>319</epage><pages>317-319</pages><issn>0253-6269</issn><eissn>1976-3786</eissn><abstract>Anticomplementary activity of hederagenin and related saponins isolated fromDipsacus asper was investigatedin vitro. HN saponin F (3) was most potent with IC₅₀ value of 3.7×10⁻⁵ M followed by 3-O-β-D-glucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyrano side (8), 3-O-β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyrano side (5) dipsacus saponin A (4), and hederagenin (1) on the classical pathway (CP) of complement system, while the saponins3–5, did not show the inhibition of hemolysis and rather increase the hemolysis on the alternative pathway (AP). However, all of C-3 monodesmosides [prosapogenin CP (2), dipsacus saponin B (6), and dipsacus saponin C (7)] evoked hemolysis directly on the erythrocytes.</abstract><pub>Pharmaceutical Society of Korea</pub><doi>10.1007/bf02976371</doi><tpages>3</tpages></addata></record> |
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| ispartof | Archives of pharmacal research, 1999-06, Vol.22 (3), p.317-319 |
| issn | 0253-6269 1976-3786 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | complement desmosides erythrocytes hemolysis inhibitory concentration 50 roots |
| title | In vitro anticomplementary activity of hederagenin saponins isolated from roots ofDipsacus asper |
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