Effect of DW2282 on the induction of methemoglobinemia, hypoglycemia or WBC count and hematological changes

DW2282,(S)-(+)-4-phenyl-1-[1-(4-aminobenzoyl)-indoline-5-sulfonyl] -4,5-dihydro-2-imidazolone hydrochloride, is a new anticancer agent which is thought to exhibit a characteristic mechanism of action in the inhibition of tumor growth. In this study, we estimated the toxicities of DW2282 in mice. Whe...

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Veröffentlicht in:	Archives of pharmacal research 1999-12, Vol.22 (6), p.565-570
Hauptverfasser:	Moon, E Y, Hwang, H S, Choi, C H, Jung, S H, Yoon, S J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - metabolism Animals Antineoplastic Agents - toxicity Aspartate Aminotransferases - metabolism Blood Cells - drug effects Blood Glucose - metabolism Body Weight - drug effects Dose-Response Relationship, Drug Hemolysis - drug effects Humans Hypoglycemia - chemically induced Imidazoles - toxicity In Vitro Techniques Male Methemoglobinemia - chemically induced Mice Sulfones - toxicity
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