Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles
The body distribution of i.v. doxorubicin depends mainly on the physicochemical characteristics of the molecule. However, entrapment of that cytostatic drug inside polyalkylcyanoacrylate nanoparticles has been shown to modify its distribution profoundly in the mouse. Polysiohexylcyanoacrylate nanopa...
Gespeichert in:
| Veröffentlicht in: | Cancer chemotherapy and pharmacology 1990-01, Vol.26 (1), p.13-18 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 18 |
|---|---|
| container_issue | 1 |
| container_start_page | 13 |
| container_title | Cancer chemotherapy and pharmacology |
| container_volume | 26 |
| creator | VERDUN, C BRASSEUR, F VRANCKX, H COUVREUR, P ROLAND, M |
| description | The body distribution of i.v. doxorubicin depends mainly on the physicochemical characteristics of the molecule. However, entrapment of that cytostatic drug inside polyalkylcyanoacrylate nanoparticles has been shown to modify its distribution profoundly in the mouse. Polysiohexylcyanoacrylate nanoparticles loaded with [14C]-doxorubicin were studied in comparison with free drug, with emphasis on their distribution pattern in mouse tissue after i.v. administration. An autoradiographic study showed that most of the radioactivity was found in the reticuloendothelial system as soon as a few minutes after i.v. administration of the doxorubicin-loaded nanoparticles. Quantitative determinations by liquid scintillation counting in fresh tissue (spleen, heart, kidneys, liver, lungs, bone marrow) and blood samples confirmed these observations. When the drug was linked to nanoparticles, doxorubicin blood clearance was reduced during the first few minutes after administration, whereas heart and kidney concentrations were substantially decreased. Assays of doxorubicin and doxorubicinol by a specific HPLC analytical method gave results very similar to those obtained by scintillation counting. |
| doi_str_mv | 10.1007/BF02940287 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF02940287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2322986</sourcerecordid><originalsourceid>FETCH-LOGICAL-c280t-f40d852ba3e3885b24345856430b4d4e626605a7a1c78b4a6d4f8177b1c1e41d3</originalsourceid><addsrcrecordid>eNpFkM9LwzAUx4Moc04v3oUePAnVl-SlzY46nAoDL_PipeRXWaRrStLh-t9b2dDT4_H58D18CLmmcE8ByoenJbA5ApPlCZlS5CwHifyUTIEj5qIEPCcXKX0BAFLOJ2TCOGNzWUzJ59qntHOZ9amPXu96H9os1JkN-xB32hvfZiqlYLzqnc2-fb_JutAMPoWN2w-NGVQblIlDM_KsHZ9Oxd6bxqVLclarJrmr452Rj-XzevGar95f3haPq9wwCX1eI1gpmFbccSmFZshRSFEgB40WXcGKAoQqFTWl1KgKi7WkZampoQ6p5TNyd9g1MaQUXV110W9VHCoK1W-f6r_PKN8c5G6nt87-qccgI789cpWMauqoWuPTn1ZIFKKg_Af6m246</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>VERDUN, C ; BRASSEUR, F ; VRANCKX, H ; COUVREUR, P ; ROLAND, M</creator><creatorcontrib>VERDUN, C ; BRASSEUR, F ; VRANCKX, H ; COUVREUR, P ; ROLAND, M</creatorcontrib><description>The body distribution of i.v. doxorubicin depends mainly on the physicochemical characteristics of the molecule. However, entrapment of that cytostatic drug inside polyalkylcyanoacrylate nanoparticles has been shown to modify its distribution profoundly in the mouse. Polysiohexylcyanoacrylate nanoparticles loaded with [14C]-doxorubicin were studied in comparison with free drug, with emphasis on their distribution pattern in mouse tissue after i.v. administration. An autoradiographic study showed that most of the radioactivity was found in the reticuloendothelial system as soon as a few minutes after i.v. administration of the doxorubicin-loaded nanoparticles. Quantitative determinations by liquid scintillation counting in fresh tissue (spleen, heart, kidneys, liver, lungs, bone marrow) and blood samples confirmed these observations. When the drug was linked to nanoparticles, doxorubicin blood clearance was reduced during the first few minutes after administration, whereas heart and kidney concentrations were substantially decreased. Assays of doxorubicin and doxorubicinol by a specific HPLC analytical method gave results very similar to those obtained by scintillation counting.</description><identifier>ISSN: 0344-5704</identifier><identifier>EISSN: 1432-0843</identifier><identifier>DOI: 10.1007/BF02940287</identifier><identifier>PMID: 2322986</identifier><identifier>CODEN: CCPHDZ</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Antineoplastic agents ; Autoradiography ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Cyanoacrylates ; Doxorubicin - administration & dosage ; Doxorubicin - pharmacokinetics ; Doxorubicin - urine ; Drug Carriers ; Feces - analysis ; General aspects ; Injections, Intravenous ; Medical sciences ; Mice ; Particle Size ; Pharmacology. Drug treatments ; Tissue Distribution</subject><ispartof>Cancer chemotherapy and pharmacology, 1990-01, Vol.26 (1), p.13-18</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-f40d852ba3e3885b24345856430b4d4e626605a7a1c78b4a6d4f8177b1c1e41d3</citedby><cites>FETCH-LOGICAL-c280t-f40d852ba3e3885b24345856430b4d4e626605a7a1c78b4a6d4f8177b1c1e41d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6845561$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2322986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VERDUN, C</creatorcontrib><creatorcontrib>BRASSEUR, F</creatorcontrib><creatorcontrib>VRANCKX, H</creatorcontrib><creatorcontrib>COUVREUR, P</creatorcontrib><creatorcontrib>ROLAND, M</creatorcontrib><title>Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles</title><title>Cancer chemotherapy and pharmacology</title><addtitle>Cancer Chemother Pharmacol</addtitle><description>The body distribution of i.v. doxorubicin depends mainly on the physicochemical characteristics of the molecule. However, entrapment of that cytostatic drug inside polyalkylcyanoacrylate nanoparticles has been shown to modify its distribution profoundly in the mouse. Polysiohexylcyanoacrylate nanoparticles loaded with [14C]-doxorubicin were studied in comparison with free drug, with emphasis on their distribution pattern in mouse tissue after i.v. administration. An autoradiographic study showed that most of the radioactivity was found in the reticuloendothelial system as soon as a few minutes after i.v. administration of the doxorubicin-loaded nanoparticles. Quantitative determinations by liquid scintillation counting in fresh tissue (spleen, heart, kidneys, liver, lungs, bone marrow) and blood samples confirmed these observations. When the drug was linked to nanoparticles, doxorubicin blood clearance was reduced during the first few minutes after administration, whereas heart and kidney concentrations were substantially decreased. Assays of doxorubicin and doxorubicinol by a specific HPLC analytical method gave results very similar to those obtained by scintillation counting.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cyanoacrylates</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - pharmacokinetics</subject><subject>Doxorubicin - urine</subject><subject>Drug Carriers</subject><subject>Feces - analysis</subject><subject>General aspects</subject><subject>Injections, Intravenous</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Particle Size</subject><subject>Pharmacology. Drug treatments</subject><subject>Tissue Distribution</subject><issn>0344-5704</issn><issn>1432-0843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9LwzAUx4Moc04v3oUePAnVl-SlzY46nAoDL_PipeRXWaRrStLh-t9b2dDT4_H58D18CLmmcE8ByoenJbA5ApPlCZlS5CwHifyUTIEj5qIEPCcXKX0BAFLOJ2TCOGNzWUzJ59qntHOZ9amPXu96H9os1JkN-xB32hvfZiqlYLzqnc2-fb_JutAMPoWN2w-NGVQblIlDM_KsHZ9Oxd6bxqVLclarJrmr452Rj-XzevGar95f3haPq9wwCX1eI1gpmFbccSmFZshRSFEgB40WXcGKAoQqFTWl1KgKi7WkZampoQ6p5TNyd9g1MaQUXV110W9VHCoK1W-f6r_PKN8c5G6nt87-qccgI789cpWMauqoWuPTn1ZIFKKg_Af6m246</recordid><startdate>19900101</startdate><enddate>19900101</enddate><creator>VERDUN, C</creator><creator>BRASSEUR, F</creator><creator>VRANCKX, H</creator><creator>COUVREUR, P</creator><creator>ROLAND, M</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19900101</creationdate><title>Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles</title><author>VERDUN, C ; BRASSEUR, F ; VRANCKX, H ; COUVREUR, P ; ROLAND, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-f40d852ba3e3885b24345856430b4d4e626605a7a1c78b4a6d4f8177b1c1e41d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cyanoacrylates</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - pharmacokinetics</topic><topic>Doxorubicin - urine</topic><topic>Drug Carriers</topic><topic>Feces - analysis</topic><topic>General aspects</topic><topic>Injections, Intravenous</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Particle Size</topic><topic>Pharmacology. Drug treatments</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VERDUN, C</creatorcontrib><creatorcontrib>BRASSEUR, F</creatorcontrib><creatorcontrib>VRANCKX, H</creatorcontrib><creatorcontrib>COUVREUR, P</creatorcontrib><creatorcontrib>ROLAND, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Cancer chemotherapy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VERDUN, C</au><au>BRASSEUR, F</au><au>VRANCKX, H</au><au>COUVREUR, P</au><au>ROLAND, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>1990-01-01</date><risdate>1990</risdate><volume>26</volume><issue>1</issue><spage>13</spage><epage>18</epage><pages>13-18</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><coden>CCPHDZ</coden><abstract>The body distribution of i.v. doxorubicin depends mainly on the physicochemical characteristics of the molecule. However, entrapment of that cytostatic drug inside polyalkylcyanoacrylate nanoparticles has been shown to modify its distribution profoundly in the mouse. Polysiohexylcyanoacrylate nanoparticles loaded with [14C]-doxorubicin were studied in comparison with free drug, with emphasis on their distribution pattern in mouse tissue after i.v. administration. An autoradiographic study showed that most of the radioactivity was found in the reticuloendothelial system as soon as a few minutes after i.v. administration of the doxorubicin-loaded nanoparticles. Quantitative determinations by liquid scintillation counting in fresh tissue (spleen, heart, kidneys, liver, lungs, bone marrow) and blood samples confirmed these observations. When the drug was linked to nanoparticles, doxorubicin blood clearance was reduced during the first few minutes after administration, whereas heart and kidney concentrations were substantially decreased. Assays of doxorubicin and doxorubicinol by a specific HPLC analytical method gave results very similar to those obtained by scintillation counting.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2322986</pmid><doi>10.1007/BF02940287</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-5704 |
| ispartof | Cancer chemotherapy and pharmacology, 1990-01, Vol.26 (1), p.13-18 |
| issn | 0344-5704 1432-0843 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF02940287 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antineoplastic agents Autoradiography Biological and medical sciences Chromatography, High Pressure Liquid Cyanoacrylates Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Doxorubicin - urine Drug Carriers Feces - analysis General aspects Injections, Intravenous Medical sciences Mice Particle Size Pharmacology. Drug treatments Tissue Distribution |
| title | Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T23%3A22%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tissue%20distribution%20of%20doxorubicin%20associated%20with%20polyisohexylcyanoacrylate%20nanoparticles&rft.jtitle=Cancer%20chemotherapy%20and%20pharmacology&rft.au=VERDUN,%20C&rft.date=1990-01-01&rft.volume=26&rft.issue=1&rft.spage=13&rft.epage=18&rft.pages=13-18&rft.issn=0344-5704&rft.eissn=1432-0843&rft.coden=CCPHDZ&rft_id=info:doi/10.1007/BF02940287&rft_dat=%3Cpubmed_cross%3E2322986%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/2322986&rfr_iscdi=true |