Intrapleural etoposide for malignant effusion

The pharmacology, toxicity, and therapeutic effectiveness of etoposide (VP-16) given by the intrapleural route were examined in a phase I trial. Ten patients with malignant pleural effusion received 100, 150, or 225 mg/m2 VP-16 infused over 2 h into the pleural space after drainage of pleural fluid....

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1990-01, Vol.26 (2), p.147-150
Hauptverfasser:	HOLOYE, P. Y, JEFFRIES, D. G, DHINGRA, H. M, HOLMES, F. A, RABER, M, ENGINEER, M. S, NEWMAN, R. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Biological and medical sciences Body Fluids - metabolism Clinical Trials as Topic Drug Evaluation Etoposide - administration & dosage Etoposide - adverse effects Etoposide - pharmacokinetics Etoposide - therapeutic use Female General aspects Humans Male Medical sciences Middle Aged Neoplasms - complications Pharmacology. Drug treatments Pleura - metabolism Pleural Effusion - drug therapy Radiography, Thoracic
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