Developmental toxicity of trichloroethylene, tetrachloroethylene and four of their metabolites in rat whole embryo culture

The embryotoxicity of trichloroethylene (TRI), tetrachloroethylene (PER), and of four of their oxidative metabolites i.e. trichloroacetic acid, dichloroacetic acid, chloral hydrate, and trichloroacetyl chloride, was studied in vitro, using the rat whole embryo culture system. Embryos from Sprague-Da...

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Veröffentlicht in:	Archives of toxicology 1995-12, Vol.70 (2), p.71-82
Hauptverfasser:	SAILLENFAIT, A. M, LANGONNE, I, SABATE, J. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chloral Hydrate - analogs & derivatives Chloral Hydrate - toxicity Chloroacetates Culture Techniques Dichloroacetic Acid - toxicity Embryo, Mammalian - drug effects Embryo, Mammalian - ultrastructure Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - drug effects Fundamental and applied biological sciences. Psychology Liver - drug effects Liver - enzymology Rats Rats, Sprague-Dawley Subcellular Fractions - drug effects Subcellular Fractions - physiology Teratology. Teratogens Tetrachloroethylene - metabolism Tetrachloroethylene - toxicity Trichloroacetic Acid - toxicity Trichloroethylene - metabolism Trichloroethylene - toxicity
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