Alkyl phosphocholines: Toxicity and anticancer properties
The study reports on the investigation of acute and subacute toxicity and on antineoplastic activity of hexadecylphosphocholine (HPC), the first compound of a new class of antineoplastic chemotherapeutics. In rats, the LD50 of HPC was 606 μmol/kg; the maximum tolerable dose over four weeks was 39 μm...
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| Veröffentlicht in: | Lipids 1987-11, Vol.22 (11), p.930-934 |
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| container_end_page | 934 |
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| container_issue | 11 |
| container_start_page | 930 |
| container_title | Lipids |
| container_volume | 22 |
| creator | Muschiol, C. Berger, M. R. Schuler, B. Scherf, H. R. Garzon, F. T. Zeller, W. J. Unger, C. Eibl, H. J. Schmähl, D. |
| description | The study reports on the investigation of acute and subacute toxicity and on antineoplastic activity of hexadecylphosphocholine (HPC), the first compound of a new class of antineoplastic chemotherapeutics. In rats, the LD50 of HPC was 606 μmol/kg; the maximum tolerable dose over four weeks was 39 μmol/kg. Symptoms of toxicity were enteritis, spider cell activation in the liver, hemosiderosis in the spleen and reversible transaminase increase. The best therapeutic effect was observed on methylnitrosourea (MNU)‐induced mammary carcinoma in the rat. Two transplantable mammary carcinomas in the rat and autochthonous benzo(a)pyrene‐induced sarcomas exhibited low‐grade sensitivity to HPC. The MXT mammary carcinoma of the mouse, the Walker 256 carcinosarcoma of the rat, and autochthonous acetoxymethylmethylnitrosamine‐induced colonic tumors of the rat were not chemosensitive to HPC. |
| doi_str_mv | 10.1007/BF02535558 |
| format | Article |
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The MXT mammary carcinoma of the mouse, the Walker 256 carcinosarcoma of the rat, and autochthonous acetoxymethylmethylnitrosamine‐induced colonic tumors of the rat were not chemosensitive to HPC.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/BF02535558</identifier><identifier>PMID: 3444388</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>Animals ; Antineoplastic Agents - therapeutic use ; Antineoplastic Agents - toxicity ; Carcinoma - drug therapy ; Choline - analogs & derivatives ; Dose-Response Relationship, Drug ; Female ; Male ; Mammary Neoplasms, Experimental - drug therapy ; Phospholipid Ethers - therapeutic use ; Phospholipid Ethers - toxicity ; Phosphorylcholine - analogs & derivatives ; Phosphorylcholine - therapeutic use ; Phosphorylcholine - toxicity ; Rats ; Rats, Inbred Strains ; Sex Factors</subject><ispartof>Lipids, 1987-11, Vol.22 (11), p.930-934</ispartof><rights>1987 American Oil Chemists' Society (AOCS)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3230-21c701095715d1523aa854e97bbf89e14ff725882ab47bffe1bd35030a468d783</citedby><cites>FETCH-LOGICAL-c3230-21c701095715d1523aa854e97bbf89e14ff725882ab47bffe1bd35030a468d783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3444388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muschiol, C.</creatorcontrib><creatorcontrib>Berger, M. R.</creatorcontrib><creatorcontrib>Schuler, B.</creatorcontrib><creatorcontrib>Scherf, H. R.</creatorcontrib><creatorcontrib>Garzon, F. T.</creatorcontrib><creatorcontrib>Zeller, W. J.</creatorcontrib><creatorcontrib>Unger, C.</creatorcontrib><creatorcontrib>Eibl, H. J.</creatorcontrib><creatorcontrib>Schmähl, D.</creatorcontrib><title>Alkyl phosphocholines: Toxicity and anticancer properties</title><title>Lipids</title><addtitle>Lipids</addtitle><description>The study reports on the investigation of acute and subacute toxicity and on antineoplastic activity of hexadecylphosphocholine (HPC), the first compound of a new class of antineoplastic chemotherapeutics. In rats, the LD50 of HPC was 606 μmol/kg; the maximum tolerable dose over four weeks was 39 μmol/kg. Symptoms of toxicity were enteritis, spider cell activation in the liver, hemosiderosis in the spleen and reversible transaminase increase. The best therapeutic effect was observed on methylnitrosourea (MNU)‐induced mammary carcinoma in the rat. Two transplantable mammary carcinomas in the rat and autochthonous benzo(a)pyrene‐induced sarcomas exhibited low‐grade sensitivity to HPC. The MXT mammary carcinoma of the mouse, the Walker 256 carcinosarcoma of the rat, and autochthonous acetoxymethylmethylnitrosamine‐induced colonic tumors of the rat were not chemosensitive to HPC.</description><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Carcinoma - drug therapy</subject><subject>Choline - analogs & derivatives</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Male</subject><subject>Mammary Neoplasms, Experimental - drug therapy</subject><subject>Phospholipid Ethers - therapeutic use</subject><subject>Phospholipid Ethers - toxicity</subject><subject>Phosphorylcholine - analogs & derivatives</subject><subject>Phosphorylcholine - therapeutic use</subject><subject>Phosphorylcholine - toxicity</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sex Factors</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LxDAUxIMoa129eBd6FqovXyb1tq6uLhT0sJ5LmiZstNuWpKL974100ZuHYXjMMPB7CJ1juMIA4vpuBYRTzrk8QAmOluUUxCFKAAjLGAF8jE5CeIsnZjmfoRlljFEpE5QvmvexSfttF6L0tmtca8Jtuum-nHbDmKq2jhqcVq02Pu191xs_OBNO0ZFVTTBne5-j19XDZvmUFc-P6-WiyDQlFDKCtQAMOReY15gTqpTkzOSiqqzMDWbWCsKlJKpiorLW4KqmHCgodiNrIekcXU672ncheGPL3rud8mOJofzBL__wY_liKvcf1c7Uv9U9b8xhyj9dY8Z_lspi_XIP8Y30GxESYh8</recordid><startdate>198711</startdate><enddate>198711</enddate><creator>Muschiol, C.</creator><creator>Berger, M. 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R.</creatorcontrib><creatorcontrib>Schuler, B.</creatorcontrib><creatorcontrib>Scherf, H. R.</creatorcontrib><creatorcontrib>Garzon, F. T.</creatorcontrib><creatorcontrib>Zeller, W. J.</creatorcontrib><creatorcontrib>Unger, C.</creatorcontrib><creatorcontrib>Eibl, H. J.</creatorcontrib><creatorcontrib>Schmähl, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muschiol, C.</au><au>Berger, M. R.</au><au>Schuler, B.</au><au>Scherf, H. R.</au><au>Garzon, F. T.</au><au>Zeller, W. J.</au><au>Unger, C.</au><au>Eibl, H. J.</au><au>Schmähl, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alkyl phosphocholines: Toxicity and anticancer properties</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>1987-11</date><risdate>1987</risdate><volume>22</volume><issue>11</issue><spage>930</spage><epage>934</epage><pages>930-934</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>The study reports on the investigation of acute and subacute toxicity and on antineoplastic activity of hexadecylphosphocholine (HPC), the first compound of a new class of antineoplastic chemotherapeutics. In rats, the LD50 of HPC was 606 μmol/kg; the maximum tolerable dose over four weeks was 39 μmol/kg. Symptoms of toxicity were enteritis, spider cell activation in the liver, hemosiderosis in the spleen and reversible transaminase increase. The best therapeutic effect was observed on methylnitrosourea (MNU)‐induced mammary carcinoma in the rat. Two transplantable mammary carcinomas in the rat and autochthonous benzo(a)pyrene‐induced sarcomas exhibited low‐grade sensitivity to HPC. The MXT mammary carcinoma of the mouse, the Walker 256 carcinosarcoma of the rat, and autochthonous acetoxymethylmethylnitrosamine‐induced colonic tumors of the rat were not chemosensitive to HPC.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>3444388</pmid><doi>10.1007/BF02535558</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-4201 |
| ispartof | Lipids, 1987-11, Vol.22 (11), p.930-934 |
| issn | 0024-4201 1558-9307 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF02535558 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Carcinoma - drug therapy Choline - analogs & derivatives Dose-Response Relationship, Drug Female Male Mammary Neoplasms, Experimental - drug therapy Phospholipid Ethers - therapeutic use Phospholipid Ethers - toxicity Phosphorylcholine - analogs & derivatives Phosphorylcholine - therapeutic use Phosphorylcholine - toxicity Rats Rats, Inbred Strains Sex Factors |
| title | Alkyl phosphocholines: Toxicity and anticancer properties |
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