Cholesterol synthesis in the pathogenesis of lithocholic acid‐induced cholestasis

Lithocholic acid (LCA)‐induced intrahepatic cholestasis is associated with increased de novo synthesis of hepatic cholesterol and augmented cholesterol content of the liver cell plasma membrane fraction enriched in bile canalicular complexes (BCM). To determine whether inhibition of cholesterol synt...

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Veröffentlicht in:	Lipids 1988-03, Vol.23 (3), p.230-233
Hauptverfasser:	Yousef, I. M., Tuchweber, B., Morazain, R., Gauvin, M., Roy, C. C., Weber, A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile - metabolism Biological and medical sciences Carbon Radioisotopes Cholestasis - chemically induced Cholestasis - metabolism Cholestasis - pathology Cholesterol - biosynthesis Clofibrate - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Hydroxymethylglutaryl-CoA Reductase Inhibitors Lithocholic Acid - metabolism Lithocholic Acid - pharmacology Liver - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Lovastatin - pharmacology Male Medical sciences Other diseases. Semiology Rats Rats, Inbred Strains
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