Determination of the retinoic acid metabolism blocking agent R115866 in human plasma by gas chromatography-high resolution mass spectrometry

A sensitive GC-MS method was developed for the determination of a new retinoic acid metabolism blocking agent R115866 in human plasma samples. A deuterium labeled internal standard (i.s.) was used. Sample preparation consisted of a one step liquid-liquid extraction, followed by derivatisation with p...

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Veröffentlicht in:	Chromatographia 2000, Vol.52 (S1), p.S109-S112
Hauptverfasser:	Verhaeghe, T, Diels, L
Format:	Artikel
Sprache:	eng
Schlagworte:	derivatization deuterium gas chromatography-mass spectrometry humans liquid-liquid extraction liquids metabolism methods retinoic acid volunteers
Online-Zugang:	Volltext
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