Enhanced antitumor efficacy with a combination of hyperthermochemotherapy and thermosensitization with polyamine antimetabolites in nude mice

In an attempt to enhance the antitumor effects of hyperthermochemotherapy, methylglyoxal-bis-guanylhydrazone (MGBG) and alpha-difluoromethylornithine (DFMO) were used in combination with hyperthermochemotherapy of 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosoure a (ACNU) agai...

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Veröffentlicht in:	Japanese journal of surgery 1987-03, Vol.17 (2), p.110-117
Hauptverfasser:	FUJIMOTO, S, SHRESTHA, R. D, OHTA, M, IGARASHI, K, ENDOH, F, KOKUBUN, M, KOIKE, S, TOGAWA, Y, OKUI, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Biological and medical sciences Chemotherapy DNA, Neoplasm - biosynthesis Eflornithine - therapeutic use Hyperthermia, Induced - methods Medical sciences Mice Mice, Inbred BALB C Mice, Nude Mitoguazone - therapeutic use Neoplasm Transplantation Nimustine Nitrosourea Compounds - therapeutic use Pharmacology. Drug treatments Polyamines - metabolism Putrescine - metabolism Spermidine - metabolism Spermine - metabolism Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Stomach Neoplasms - therapy Time Factors
Online-Zugang:	Volltext
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