Release and elimination of methylmethacrylate monomer after intraocular lens implantation

The potential for certain constituents in intraocular lenses, such as monomer methylmethacrylate (MMM), to induce toxic effects after intraocular implantation not only depends on their toxic potency, but also on the characteristics of their release, accumulation, and elimination from the aqueous hum...

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Veröffentlicht in:	Graefe's archive for clinical and experimental ophthalmology 1987-01, Vol.225 (6), p.426-428
Hauptverfasser:	LUDWIG, K, SCHEIFFARTH, O. F, LUND, O.-E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Eye - metabolism Humans Lenses, Intraocular Mathematics Medical sciences Methylmethacrylate Methylmethacrylates - pharmacokinetics Models, Theoretical Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit
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creator	LUDWIG, K SCHEIFFARTH, O. F LUND, O.-E
description	The potential for certain constituents in intraocular lenses, such as monomer methylmethacrylate (MMM), to induce toxic effects after intraocular implantation not only depends on their toxic potency, but also on the characteristics of their release, accumulation, and elimination from the aqueous humor. A mathematical estimation taking these factors into account shows that for a lens mass of approximately 15 mg, the concentration of MMM in the aqueous humor amounts to about 10(-4) of the respective concentration in the lens, but that value is maintained for several weeks. Therefore, experiments to test the chemical toxicity of MMM or similar lens compounds in eyes must not only take into account the actual concentration limit but also the time of exposure to the substance.
doi_str_mv	10.1007/BF02334170
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Therefore, experiments to test the chemical toxicity of MMM or similar lens compounds in eyes must not only take into account the actual concentration limit but also the time of exposure to the substance.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/BF02334170</identifier><identifier>PMID: 3678853</identifier><identifier>CODEN: GACODL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Biological and medical sciences ; Eye - metabolism ; Humans ; Lenses, Intraocular ; Mathematics ; Medical sciences ; Methylmethacrylate ; Methylmethacrylates - pharmacokinetics ; Models, Theoretical ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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Therefore, experiments to test the chemical toxicity of MMM or similar lens compounds in eyes must not only take into account the actual concentration limit but also the time of exposure to the substance.</description><subject>Biological and medical sciences</subject><subject>Eye - metabolism</subject><subject>Humans</subject><subject>Lenses, Intraocular</subject><subject>Mathematics</subject><subject>Medical sciences</subject><subject>Methylmethacrylate</subject><subject>Methylmethacrylates - pharmacokinetics</subject><subject>Models, Theoretical</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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source	MEDLINE; Springer Nature - Complete Springer Journals
subjects	Biological and medical sciences Eye - metabolism Humans Lenses, Intraocular Mathematics Medical sciences Methylmethacrylate Methylmethacrylates - pharmacokinetics Models, Theoretical Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit
title	Release and elimination of methylmethacrylate monomer after intraocular lens implantation
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