Complex effects of age and gender on hypothermic, adrenocorticotrophic hormone and cortisol responses to ipsapirone challenge in normal subjects

The effects of a challenge dose of the 5-HT1A agonist, ipsapirone (0.3 mg per kg body weight), or placebo on body temperature and on adrenocorticotrophic hormone (ACTH) and cortisol release, were examined in 30 normal subjects (14 males, 19-74 years and 16 females, 22-69 years) using a randomized, d...

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Veröffentlicht in:	Psychopharmacologia 1995-08, Vol.120 (3), p.356-364
Hauptverfasser:	GELFIN, Y, LERER, B, LESCH, K.-P, GORFINE, M, ALLOLIO, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - blood Adrenocorticotropic Hormone - metabolism Adult Age Factors Aged Aging Biological and medical sciences Blood Pressure - drug effects Body Temperature - drug effects Female Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Humans Hydrocortisone - blood Hydrocortisone - metabolism Hypothermia Male Middle Aged Placebo Effect Pyrimidines - adverse effects Pyrimidines - pharmacology Serotonin - pharmacology Serotonin Receptor Agonists - adverse effects Serotonin Receptor Agonists - pharmacology Sex Factors Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Time Factors Vertebrates: anatomy and physiology, studies on body, several organs or systems
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