Isoproterenol-induced gastric mucosal protection from bile acid : role of endogenous prostaglandins

Topical isoproterenol is a potent protective agent against bile acid-induced gastric mucosal injury in hypotensive and normotensive rats. This study was undertaken to ascertain what role endogenous prostaglandins and gastric mucosal blood flow play in isoproterenol-induced protection. Accordingly, a...

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Veröffentlicht in:	Digestive diseases and sciences 1995-10, Vol.40 (10), p.2227-2235
Hauptverfasser:	MERCER, D. W, MERCHANT, N. B, RITCHIE, W. P, DEMPSEY, D. T
Format:	Artikel
Sprache:	eng
Schlagworte:	16,16-Dimethylprostaglandin E2 - analysis 16,16-Dimethylprostaglandin E2 - pharmacology Analysis of Variance Animals Bile Acids and Salts - toxicity Biological and medical sciences Cyclooxygenase Inhibitors - pharmacology Drug Interactions Gastric Mucosa - blood supply Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology General pharmacology Indomethacin - pharmacology Isoproterenol - pharmacology Medical sciences Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Prostaglandins - physiology Random Allocation Rats Rats, Sprague-Dawley Regional Blood Flow - drug effects
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