Induction of chromosomal aberrations by the anthracycline antitumor antibiotics N,N-dimethyldaunomycin and aclacinomycin A
The clastogenic effect of the anthracycline antitumor antibiotics, N,N-dimethyldaunomycin and aclarcinomycin A, was studied in a murine hemopoietic cell line (Friend leukemia cells). A dose-dependent increase in chromatid lesions, i.e., achromatic lesions, chromatid breaks, chromatid deletions and t...
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| Veröffentlicht in: | Experientia 1987-05, Vol.43 (5), p.586-588 |
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| creator | STEINHEIDER, G WESTENDORF, J MARQUARDT, H |
| description | The clastogenic effect of the anthracycline antitumor antibiotics, N,N-dimethyldaunomycin and aclarcinomycin A, was studied in a murine hemopoietic cell line (Friend leukemia cells). A dose-dependent increase in chromatid lesions, i.e., achromatic lesions, chromatid breaks, chromatid deletions and triradial or quandriradial chromosomal exchange fiqures, was found. It appears that the clastogenicity of N,N-dimethyldaunomycin and aclacinomycin A is lower than that of the classic anthracycline, daunomycin, which is also a potent mutagen and carcinogen. The data demonstrate that the capacity of chemicals to induce point mutations and chromosomal aberrations may not necessarily be correlated: aclacinomycin A is devoid of mutagenic activity in bacterial (Salmonella typh.) and mammalian cell (HGPRT) mutagenesis assays, and is non-carcinogenic in rats. Nevertheless, it was now found to possess clastogenic activity. |
| doi_str_mv | 10.1007/BF02143595 |
| format | Article |
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A dose-dependent increase in chromatid lesions, i.e., achromatic lesions, chromatid breaks, chromatid deletions and triradial or quandriradial chromosomal exchange fiqures, was found. It appears that the clastogenicity of N,N-dimethyldaunomycin and aclacinomycin A is lower than that of the classic anthracycline, daunomycin, which is also a potent mutagen and carcinogen. The data demonstrate that the capacity of chemicals to induce point mutations and chromosomal aberrations may not necessarily be correlated: aclacinomycin A is devoid of mutagenic activity in bacterial (Salmonella typh.) and mammalian cell (HGPRT) mutagenesis assays, and is non-carcinogenic in rats. Nevertheless, it was now found to possess clastogenic activity.</description><identifier>ISSN: 0014-4754</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/BF02143595</identifier><identifier>PMID: 3472901</identifier><identifier>CODEN: EXPEAM</identifier><language>eng</language><publisher>Basel: Birkhäuser</publisher><subject>Aclarubicin ; Animals ; Antibiotics, Antineoplastic - pharmacology ; Biological and medical sciences ; Cell Line ; Chromosome Aberrations ; Daunorubicin - analogs & derivatives ; Daunorubicin - pharmacology ; Drug toxicity and drugs side effects treatment ; Leukemia, Erythroblastic, Acute ; Leukemia, Experimental ; Medical sciences ; Mice ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Mutation ; Naphthacenes - pharmacology ; Pharmacology. 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A dose-dependent increase in chromatid lesions, i.e., achromatic lesions, chromatid breaks, chromatid deletions and triradial or quandriradial chromosomal exchange fiqures, was found. It appears that the clastogenicity of N,N-dimethyldaunomycin and aclacinomycin A is lower than that of the classic anthracycline, daunomycin, which is also a potent mutagen and carcinogen. The data demonstrate that the capacity of chemicals to induce point mutations and chromosomal aberrations may not necessarily be correlated: aclacinomycin A is devoid of mutagenic activity in bacterial (Salmonella typh.) and mammalian cell (HGPRT) mutagenesis assays, and is non-carcinogenic in rats. Nevertheless, it was now found to possess clastogenic activity.</description><subject>Aclarubicin</subject><subject>Animals</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Chromosome Aberrations</subject><subject>Daunorubicin - analogs & derivatives</subject><subject>Daunorubicin - pharmacology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Leukemia, Erythroblastic, Acute</subject><subject>Leukemia, Experimental</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Mutation</subject><subject>Naphthacenes - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><issn>0014-4754</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDlPxTAQhC0EgsfR0COlQBSIwPpK4hIQl4SggTpaH9EzSmKwkyL8egJEUO3szKcphpBDCucUoLy4ugVGBZdKbpAVFQxyBSXdJCsAKnJRSrFDdlN6A-AgabFNtrkomQK6Ip8PvR3N4EOfhSYz6xi6kEKHbYbaxYjfScr0lA1rl2E_rCOaybS-__n8MHYh_ijtw-BNyp7OnnLrOzesp9bi2IduMr6fEZuhaXHWi3O5T7YabJM7WO4eeb29ebm-zx-f7x6uLx9zwwUb8lKDLKUSjaJFZTVoVTlKbWUdOuagcIo2wFXTMMsMLSQWymhUzGlaCi053yMnv73vMXyMLg1155NxbYu9C2OqqVCgQMoZPP0FTQwpRdfU79F3GKeaQv09dP0_9AwfLa2j7pz9Q5dl5_x4yTEZbJuIvfHpD6uY4KwS_AtGroc_</recordid><startdate>19870515</startdate><enddate>19870515</enddate><creator>STEINHEIDER, G</creator><creator>WESTENDORF, J</creator><creator>MARQUARDT, H</creator><general>Birkhäuser</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19870515</creationdate><title>Induction of chromosomal aberrations by the anthracycline antitumor antibiotics N,N-dimethyldaunomycin and aclacinomycin A</title><author>STEINHEIDER, G ; WESTENDORF, J ; MARQUARDT, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-7b057594f9168db0b98e11d8deae2e06e91f039ff2d2c165a69cba92eb174b533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aclarubicin</topic><topic>Animals</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Chromosome Aberrations</topic><topic>Daunorubicin - analogs & derivatives</topic><topic>Daunorubicin - pharmacology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Leukemia, Erythroblastic, Acute</topic><topic>Leukemia, Experimental</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Mutation</topic><topic>Naphthacenes - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STEINHEIDER, G</creatorcontrib><creatorcontrib>WESTENDORF, J</creatorcontrib><creatorcontrib>MARQUARDT, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Experientia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STEINHEIDER, G</au><au>WESTENDORF, J</au><au>MARQUARDT, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of chromosomal aberrations by the anthracycline antitumor antibiotics N,N-dimethyldaunomycin and aclacinomycin A</atitle><jtitle>Experientia</jtitle><addtitle>Experientia</addtitle><date>1987-05-15</date><risdate>1987</risdate><volume>43</volume><issue>5</issue><spage>586</spage><epage>588</epage><pages>586-588</pages><issn>0014-4754</issn><eissn>1420-9071</eissn><coden>EXPEAM</coden><abstract>The clastogenic effect of the anthracycline antitumor antibiotics, N,N-dimethyldaunomycin and aclarcinomycin A, was studied in a murine hemopoietic cell line (Friend leukemia cells). A dose-dependent increase in chromatid lesions, i.e., achromatic lesions, chromatid breaks, chromatid deletions and triradial or quandriradial chromosomal exchange fiqures, was found. It appears that the clastogenicity of N,N-dimethyldaunomycin and aclacinomycin A is lower than that of the classic anthracycline, daunomycin, which is also a potent mutagen and carcinogen. The data demonstrate that the capacity of chemicals to induce point mutations and chromosomal aberrations may not necessarily be correlated: aclacinomycin A is devoid of mutagenic activity in bacterial (Salmonella typh.) and mammalian cell (HGPRT) mutagenesis assays, and is non-carcinogenic in rats. Nevertheless, it was now found to possess clastogenic activity.</abstract><cop>Basel</cop><cop>Boston, MA</cop><cop>Berlin</cop><pub>Birkhäuser</pub><pmid>3472901</pmid><doi>10.1007/BF02143595</doi><tpages>3</tpages></addata></record> |
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| ispartof | Experientia, 1987-05, Vol.43 (5), p.586-588 |
| issn | 0014-4754 1420-9071 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aclarubicin Animals Antibiotics, Antineoplastic - pharmacology Biological and medical sciences Cell Line Chromosome Aberrations Daunorubicin - analogs & derivatives Daunorubicin - pharmacology Drug toxicity and drugs side effects treatment Leukemia, Erythroblastic, Acute Leukemia, Experimental Medical sciences Mice Miscellaneous (drug allergy, mutagens, teratogens...) Mutation Naphthacenes - pharmacology Pharmacology. Drug treatments |
| title | Induction of chromosomal aberrations by the anthracycline antitumor antibiotics N,N-dimethyldaunomycin and aclacinomycin A |
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