Hepatic stimulator substance administration enhances regenerative capacity of hepatocytes in cadmium-pretreated partially hepatectomized rats
The liver is of central importance in the metabolism of essential and toxic metals such as cadmium (Cd). Cd pretreatment suppressed the regenerative capacity of hepatocytes, which normally occurs 24 hr after partial hepatectomy, due to the inhibition of the activity of the enzyme thymidine kinase. T...
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| Veröffentlicht in: | Digestive diseases and sciences 1996-07, Vol.41 (7), p.1475-1480 |
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| container_title | Digestive diseases and sciences |
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| creator | THEOCHARIS, S. E MARGELI, A. P SPILIOPOULOU, C SKALTSAS, S KITTAS, C KOUTSELINIS, A |
| description | The liver is of central importance in the metabolism of essential and toxic metals such as cadmium (Cd). Cd pretreatment suppressed the regenerative capacity of hepatocytes, which normally occurs 24 hr after partial hepatectomy, due to the inhibition of the activity of the enzyme thymidine kinase. The effect of hepatic stimulator substance (HSS) administration (10, 20, and 40 mg protein/kg body weight) on hepatocyte proliferation was investigated in Cd-pretreated partially hepatectomized rats. HSS administration partly restored the suppressed hepatocyte DNA biosynthesis in Cd-pretreated partially hepatectomized rats. The hepatocyte mitotic activity and the percentage of proliferating cell nuclear antigen-positive nuclei were in accordance with the liver proliferative status. The administration of HSS did not affect in a statistically significant manner the activity of the enzyme thymidine kinase in Cd-pretreated partially hepatectomized rats. It is suggested that the administration of HSS ameliorates the diminished hepatocyte regenerative response to partial hepatectomy in this model of acute liver injury, due to Cd intoxication. |
| doi_str_mv | 10.1007/BF02088575 |
| format | Article |
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E ; MARGELI, A. P ; SPILIOPOULOU, C ; SKALTSAS, S ; KITTAS, C ; KOUTSELINIS, A</creator><creatorcontrib>THEOCHARIS, S. E ; MARGELI, A. P ; SPILIOPOULOU, C ; SKALTSAS, S ; KITTAS, C ; KOUTSELINIS, A</creatorcontrib><description>The liver is of central importance in the metabolism of essential and toxic metals such as cadmium (Cd). Cd pretreatment suppressed the regenerative capacity of hepatocytes, which normally occurs 24 hr after partial hepatectomy, due to the inhibition of the activity of the enzyme thymidine kinase. The effect of hepatic stimulator substance (HSS) administration (10, 20, and 40 mg protein/kg body weight) on hepatocyte proliferation was investigated in Cd-pretreated partially hepatectomized rats. HSS administration partly restored the suppressed hepatocyte DNA biosynthesis in Cd-pretreated partially hepatectomized rats. The hepatocyte mitotic activity and the percentage of proliferating cell nuclear antigen-positive nuclei were in accordance with the liver proliferative status. The administration of HSS did not affect in a statistically significant manner the activity of the enzyme thymidine kinase in Cd-pretreated partially hepatectomized rats. It is suggested that the administration of HSS ameliorates the diminished hepatocyte regenerative response to partial hepatectomy in this model of acute liver injury, due to Cd intoxication.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF02088575</identifier><identifier>PMID: 8689927</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Biological and medical sciences ; Cadmium - toxicity ; Cell Division - drug effects ; Digestive system ; DNA - biosynthesis ; Growth Substances - pharmacology ; Hepatectomy ; Intercellular Signaling Peptides and Proteins ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver Regeneration - drug effects ; Male ; Medical sciences ; Mitogens - pharmacology ; Peptides - pharmacology ; Pharmacology. Drug treatments ; Proliferating Cell Nuclear Antigen - analysis ; Rats ; Rats, Wistar ; Thymidine Kinase - metabolism</subject><ispartof>Digestive diseases and sciences, 1996-07, Vol.41 (7), p.1475-1480</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-4f68ea2e66500459b6ceb21affd0e397ffd9cf069eef7e3cb776810c42890eed3</citedby><cites>FETCH-LOGICAL-c311t-4f68ea2e66500459b6ceb21affd0e397ffd9cf069eef7e3cb776810c42890eed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3169909$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8689927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THEOCHARIS, S. E</creatorcontrib><creatorcontrib>MARGELI, A. P</creatorcontrib><creatorcontrib>SPILIOPOULOU, C</creatorcontrib><creatorcontrib>SKALTSAS, S</creatorcontrib><creatorcontrib>KITTAS, C</creatorcontrib><creatorcontrib>KOUTSELINIS, A</creatorcontrib><title>Hepatic stimulator substance administration enhances regenerative capacity of hepatocytes in cadmium-pretreated partially hepatectomized rats</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>The liver is of central importance in the metabolism of essential and toxic metals such as cadmium (Cd). Cd pretreatment suppressed the regenerative capacity of hepatocytes, which normally occurs 24 hr after partial hepatectomy, due to the inhibition of the activity of the enzyme thymidine kinase. The effect of hepatic stimulator substance (HSS) administration (10, 20, and 40 mg protein/kg body weight) on hepatocyte proliferation was investigated in Cd-pretreated partially hepatectomized rats. HSS administration partly restored the suppressed hepatocyte DNA biosynthesis in Cd-pretreated partially hepatectomized rats. The hepatocyte mitotic activity and the percentage of proliferating cell nuclear antigen-positive nuclei were in accordance with the liver proliferative status. The administration of HSS did not affect in a statistically significant manner the activity of the enzyme thymidine kinase in Cd-pretreated partially hepatectomized rats. It is suggested that the administration of HSS ameliorates the diminished hepatocyte regenerative response to partial hepatectomy in this model of acute liver injury, due to Cd intoxication.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cadmium - toxicity</subject><subject>Cell Division - drug effects</subject><subject>Digestive system</subject><subject>DNA - biosynthesis</subject><subject>Growth Substances - pharmacology</subject><subject>Hepatectomy</subject><subject>Intercellular Signaling Peptides and Proteins</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Regeneration - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mitogens - pharmacology</subject><subject>Peptides - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Proliferating Cell Nuclear Antigen - analysis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Thymidine Kinase - metabolism</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEURYMotVY37oUsXAmjLzOdZLLUYq1QcKPrksm82Mh8kWSE-h_8z2Zoqav7eOdwF5eQawb3DEA8PC0hhaLIRX5CpiwXWZLmvDglU2A83ozxc3Lh_RcASMH4hEwKXkiZiin5XWGvgtXUB9sMtQqdo34ofVCtRqqqxrbWBxeVrqXYbse3pw4_scXx-41Uq15pG3a0M3Q7tnV6F6Jk24hiwdAkvcPgUAWsaK9csKqud3sXdega-xNBbPOX5Myo2uPVIWfkY_n8vlgl67eX18XjOtEZYyGZG16gSpHzHGCey5JrLFOmjKkAMyliSm2AS0QjMNOlELxgoOdpIQGxymbkbt-rXee9Q7PpnW2U220YbMZJN_-TRvlmL_dD2WB1VA8bRn574MprVRsXN7L-qGWMSwky-wMQE4M_</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>THEOCHARIS, S. E</creator><creator>MARGELI, A. 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P ; SPILIOPOULOU, C ; SKALTSAS, S ; KITTAS, C ; KOUTSELINIS, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-4f68ea2e66500459b6ceb21affd0e397ffd9cf069eef7e3cb776810c42890eed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cadmium - toxicity</topic><topic>Cell Division - drug effects</topic><topic>Digestive system</topic><topic>DNA - biosynthesis</topic><topic>Growth Substances - pharmacology</topic><topic>Hepatectomy</topic><topic>Intercellular Signaling Peptides and Proteins</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Regeneration - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mitogens - pharmacology</topic><topic>Peptides - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Proliferating Cell Nuclear Antigen - analysis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Thymidine Kinase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THEOCHARIS, S. E</creatorcontrib><creatorcontrib>MARGELI, A. P</creatorcontrib><creatorcontrib>SPILIOPOULOU, C</creatorcontrib><creatorcontrib>SKALTSAS, S</creatorcontrib><creatorcontrib>KITTAS, C</creatorcontrib><creatorcontrib>KOUTSELINIS, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THEOCHARIS, S. E</au><au>MARGELI, A. 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The effect of hepatic stimulator substance (HSS) administration (10, 20, and 40 mg protein/kg body weight) on hepatocyte proliferation was investigated in Cd-pretreated partially hepatectomized rats. HSS administration partly restored the suppressed hepatocyte DNA biosynthesis in Cd-pretreated partially hepatectomized rats. The hepatocyte mitotic activity and the percentage of proliferating cell nuclear antigen-positive nuclei were in accordance with the liver proliferative status. The administration of HSS did not affect in a statistically significant manner the activity of the enzyme thymidine kinase in Cd-pretreated partially hepatectomized rats. It is suggested that the administration of HSS ameliorates the diminished hepatocyte regenerative response to partial hepatectomy in this model of acute liver injury, due to Cd intoxication.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>8689927</pmid><doi>10.1007/BF02088575</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 1996-07, Vol.41 (7), p.1475-1480 |
| issn | 0163-2116 1573-2568 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biological and medical sciences Cadmium - toxicity Cell Division - drug effects Digestive system DNA - biosynthesis Growth Substances - pharmacology Hepatectomy Intercellular Signaling Peptides and Proteins Liver - drug effects Liver - metabolism Liver - pathology Liver Regeneration - drug effects Male Medical sciences Mitogens - pharmacology Peptides - pharmacology Pharmacology. Drug treatments Proliferating Cell Nuclear Antigen - analysis Rats Rats, Wistar Thymidine Kinase - metabolism |
| title | Hepatic stimulator substance administration enhances regenerative capacity of hepatocytes in cadmium-pretreated partially hepatectomized rats |
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