Functional ablation of sensory neurons impairs healing of acute gastric mucosal damage in rats

Healing of ethanol-injured gastric mucosa was studied in rats treated with a neurotoxic dose of capsaicin to induce functional ablation of sensory nerves. Capsaicin treatment delayed the healing of mucosal damage in the glandular region and promoted the development of deep ulcerations predominantly...

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Veröffentlicht in:	Digestive diseases and sciences 1995-11, Vol.40 (11), p.2460-2464
Hauptverfasser:	PESKAR, B. M, LAMBRECHT, N, STROFF, T, RESPONDEK, M, MÜLLER, K.-M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Capsaicin Ethanol Gastric Mucosa - drug effects Gastric Mucosa - innervation Gastric Mucosa - metabolism Gastric Mucosa - pathology Gastroenterology. Liver. Pancreas. Abdomen Male Medical sciences Neurons, Afferent - physiology NG-Nitroarginine Methyl Ester Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Other diseases. Semiology Peroxidase - metabolism Rats Rats, Wistar Stomach Ulcer - chemically induced Stomach Ulcer - metabolism Stomach Ulcer - pathology Stomach Ulcer - physiopathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Wound Healing - physiology
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