Stimulation of CRP secretion in HepG2 cells: cooperative effect of dexamethasone and interleukin 6
This report described the capability of the human. human acute phase reactant, C-reactive protein (CRP). Its secretion is stimulated by interleukin 6 (IL-6) in a dose-dependent fashion and can further be positively modulated by dexamethasone. The way in which this glucocorticoid influences the CRP r...
Gespeichert in:
| Veröffentlicht in: | Agents and Actions 1991-11, Vol.34 (3-4), p.369-375 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 375 |
|---|---|
| container_issue | 3-4 |
| container_start_page | 369 |
| container_title | Agents and Actions |
| container_volume | 34 |
| creator | Depraetere, S Willems, J Joniau, M |
| description | This report described the capability of the human. human acute phase reactant, C-reactive protein (CRP). Its secretion is stimulated by interleukin 6 (IL-6) in a dose-dependent fashion and can further be positively modulated by dexamethasone. The way in which this glucocorticoid influences the CRP response depends on its time of application. Incubation of HepG2 cells simultaneously with IL-6 and dexamethasone increases the magnitude of CRP release significantly above that seen with IL-6 alone. After preincubation with dexamethasone, the kinetics of CRP release, induced by IL-6, are increased and approach that observed in the case of alpha 1-acid glycoprotein (alpha 1-AGP) without dexamethasone pretreatment. Conditions for optimal secretion of CRP were determined. |
| doi_str_mv | 10.1007/bf01988730 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF01988730</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1667244</sourcerecordid><originalsourceid>FETCH-LOGICAL-c348t-1de7498bf9e5b13c851e14f077212e7aaf181628d52290e22e67bf251a00be013</originalsourceid><addsrcrecordid>eNpFkEtLAzEUhYMotVY37oWshdF7M48k7rTYVhAUH-BuSDI3ODovJlPRf-_UKq4uHL5zuHyMHSOcIYA8tx5QKyVj2GFTTAREGtTLLpsCZGmUCK332UEIbwBpigonbIJZJkWSTJl9HMp6XZmhbBveej5_uOeBXE8_QdnwFXVLwR1VVbjgrm076kf4gzh5T27YdAr6NDUNrya0DXHTFGNvoL6i9fs4kB2yPW-qQEe_d8aeF9dP81V0e7e8mV_eRi5O1BBhQTLRynpNqcXYqRQJEw9SChQkjfHj65lQRSqEBhKCMmm9SNEAWAKMZ-x0u-v6NoSefN71ZW36rxwh33jKrxZ_nkb4ZAt3a1tT8Y9uxcTfy-FiRw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Stimulation of CRP secretion in HepG2 cells: cooperative effect of dexamethasone and interleukin 6</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Depraetere, S ; Willems, J ; Joniau, M</creator><creatorcontrib>Depraetere, S ; Willems, J ; Joniau, M</creatorcontrib><description>This report described the capability of the human. human acute phase reactant, C-reactive protein (CRP). Its secretion is stimulated by interleukin 6 (IL-6) in a dose-dependent fashion and can further be positively modulated by dexamethasone. The way in which this glucocorticoid influences the CRP response depends on its time of application. Incubation of HepG2 cells simultaneously with IL-6 and dexamethasone increases the magnitude of CRP release significantly above that seen with IL-6 alone. After preincubation with dexamethasone, the kinetics of CRP release, induced by IL-6, are increased and approach that observed in the case of alpha 1-acid glycoprotein (alpha 1-AGP) without dexamethasone pretreatment. Conditions for optimal secretion of CRP were determined.</description><identifier>ISSN: 0065-4299</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/bf01988730</identifier><identifier>PMID: 1667244</identifier><language>eng</language><publisher>Switzerland</publisher><subject>C-Reactive Protein - biosynthesis ; C-Reactive Protein - metabolism ; Carcinoma, Hepatocellular - metabolism ; Dexamethasone - pharmacology ; Drug Interactions ; Humans ; Interleukin-6 - pharmacology ; Kinetics ; Liver Neoplasms - metabolism ; Tumor Cells, Cultured</subject><ispartof>Agents and Actions, 1991-11, Vol.34 (3-4), p.369-375</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-1de7498bf9e5b13c851e14f077212e7aaf181628d52290e22e67bf251a00be013</citedby><cites>FETCH-LOGICAL-c348t-1de7498bf9e5b13c851e14f077212e7aaf181628d52290e22e67bf251a00be013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1667244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Depraetere, S</creatorcontrib><creatorcontrib>Willems, J</creatorcontrib><creatorcontrib>Joniau, M</creatorcontrib><title>Stimulation of CRP secretion in HepG2 cells: cooperative effect of dexamethasone and interleukin 6</title><title>Agents and Actions</title><addtitle>Agents Actions</addtitle><description>This report described the capability of the human. human acute phase reactant, C-reactive protein (CRP). Its secretion is stimulated by interleukin 6 (IL-6) in a dose-dependent fashion and can further be positively modulated by dexamethasone. The way in which this glucocorticoid influences the CRP response depends on its time of application. Incubation of HepG2 cells simultaneously with IL-6 and dexamethasone increases the magnitude of CRP release significantly above that seen with IL-6 alone. After preincubation with dexamethasone, the kinetics of CRP release, induced by IL-6, are increased and approach that observed in the case of alpha 1-acid glycoprotein (alpha 1-AGP) without dexamethasone pretreatment. Conditions for optimal secretion of CRP were determined.</description><subject>C-Reactive Protein - biosynthesis</subject><subject>C-Reactive Protein - metabolism</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Dexamethasone - pharmacology</subject><subject>Drug Interactions</subject><subject>Humans</subject><subject>Interleukin-6 - pharmacology</subject><subject>Kinetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Tumor Cells, Cultured</subject><issn>0065-4299</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEUhYMotVY37oWshdF7M48k7rTYVhAUH-BuSDI3ODovJlPRf-_UKq4uHL5zuHyMHSOcIYA8tx5QKyVj2GFTTAREGtTLLpsCZGmUCK332UEIbwBpigonbIJZJkWSTJl9HMp6XZmhbBveej5_uOeBXE8_QdnwFXVLwR1VVbjgrm076kf4gzh5T27YdAr6NDUNrya0DXHTFGNvoL6i9fs4kB2yPW-qQEe_d8aeF9dP81V0e7e8mV_eRi5O1BBhQTLRynpNqcXYqRQJEw9SChQkjfHj65lQRSqEBhKCMmm9SNEAWAKMZ-x0u-v6NoSefN71ZW36rxwh33jKrxZ_nkb4ZAt3a1tT8Y9uxcTfy-FiRw</recordid><startdate>199111</startdate><enddate>199111</enddate><creator>Depraetere, S</creator><creator>Willems, J</creator><creator>Joniau, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199111</creationdate><title>Stimulation of CRP secretion in HepG2 cells: cooperative effect of dexamethasone and interleukin 6</title><author>Depraetere, S ; Willems, J ; Joniau, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-1de7498bf9e5b13c851e14f077212e7aaf181628d52290e22e67bf251a00be013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>C-Reactive Protein - biosynthesis</topic><topic>C-Reactive Protein - metabolism</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Dexamethasone - pharmacology</topic><topic>Drug Interactions</topic><topic>Humans</topic><topic>Interleukin-6 - pharmacology</topic><topic>Kinetics</topic><topic>Liver Neoplasms - metabolism</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Depraetere, S</creatorcontrib><creatorcontrib>Willems, J</creatorcontrib><creatorcontrib>Joniau, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Agents and Actions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Depraetere, S</au><au>Willems, J</au><au>Joniau, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulation of CRP secretion in HepG2 cells: cooperative effect of dexamethasone and interleukin 6</atitle><jtitle>Agents and Actions</jtitle><addtitle>Agents Actions</addtitle><date>1991-11</date><risdate>1991</risdate><volume>34</volume><issue>3-4</issue><spage>369</spage><epage>375</epage><pages>369-375</pages><issn>0065-4299</issn><eissn>1420-908X</eissn><abstract>This report described the capability of the human. human acute phase reactant, C-reactive protein (CRP). Its secretion is stimulated by interleukin 6 (IL-6) in a dose-dependent fashion and can further be positively modulated by dexamethasone. The way in which this glucocorticoid influences the CRP response depends on its time of application. Incubation of HepG2 cells simultaneously with IL-6 and dexamethasone increases the magnitude of CRP release significantly above that seen with IL-6 alone. After preincubation with dexamethasone, the kinetics of CRP release, induced by IL-6, are increased and approach that observed in the case of alpha 1-acid glycoprotein (alpha 1-AGP) without dexamethasone pretreatment. Conditions for optimal secretion of CRP were determined.</abstract><cop>Switzerland</cop><pmid>1667244</pmid><doi>10.1007/bf01988730</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0065-4299 |
| ispartof | Agents and Actions, 1991-11, Vol.34 (3-4), p.369-375 |
| issn | 0065-4299 1420-908X |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01988730 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | C-Reactive Protein - biosynthesis C-Reactive Protein - metabolism Carcinoma, Hepatocellular - metabolism Dexamethasone - pharmacology Drug Interactions Humans Interleukin-6 - pharmacology Kinetics Liver Neoplasms - metabolism Tumor Cells, Cultured |
| title | Stimulation of CRP secretion in HepG2 cells: cooperative effect of dexamethasone and interleukin 6 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T04%3A31%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stimulation%20of%20CRP%20secretion%20in%20HepG2%20cells:%20cooperative%20effect%20of%20dexamethasone%20and%20interleukin%206&rft.jtitle=Agents%20and%20Actions&rft.au=Depraetere,%20S&rft.date=1991-11&rft.volume=34&rft.issue=3-4&rft.spage=369&rft.epage=375&rft.pages=369-375&rft.issn=0065-4299&rft.eissn=1420-908X&rft_id=info:doi/10.1007/bf01988730&rft_dat=%3Cpubmed_cross%3E1667244%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/1667244&rfr_iscdi=true |