Ketotifen-induced histamine release, inhibition of histamine secretion and modulation of immune response
In concentrations above 0.1 mM Ketotifen (KT) induced secretion of histamine from rat and mouse mast cells, but not from human basophils. In the same concentrations KT inhibited histamine release from rat mast cells, induced by compound 48/80 and histamine release from basophils, induced by anti-IgE...
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| Veröffentlicht in: | Agents and Actions 1986-04, Vol.18 (1-2), p.92-95 |
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| container_title | Agents and Actions |
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| creator | Gushchin, I S Zebrev, A I |
| description | In concentrations above 0.1 mM Ketotifen (KT) induced secretion of histamine from rat and mouse mast cells, but not from human basophils. In the same concentrations KT inhibited histamine release from rat mast cells, induced by compound 48/80 and histamine release from basophils, induced by anti-IgE-antibodies and concanavalin A. At low concentration (0.05-0.005 mM) KT enhanced in vitro phytohemagglutinin-induced proliferative response of human lymphocytes. The immunostimulating effect of KT was confirmed in vivo. In doses 0.18-1.4 micrograms/mouse KT significantly increased the number of antibody-producing cells (APC) in spleens of mice immunized by sheep red blood cells (SRBC). KT stimulated both IgM- and IgG-immune response to SRBC. |
| doi_str_mv | 10.1007/BF01987992 |
| format | Article |
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In the same concentrations KT inhibited histamine release from rat mast cells, induced by compound 48/80 and histamine release from basophils, induced by anti-IgE-antibodies and concanavalin A. At low concentration (0.05-0.005 mM) KT enhanced in vitro phytohemagglutinin-induced proliferative response of human lymphocytes. The immunostimulating effect of KT was confirmed in vivo. In doses 0.18-1.4 micrograms/mouse KT significantly increased the number of antibody-producing cells (APC) in spleens of mice immunized by sheep red blood cells (SRBC). KT stimulated both IgM- and IgG-immune response to SRBC.</description><identifier>ISSN: 0065-4299</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/BF01987992</identifier><identifier>PMID: 2425601</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Animals ; Dose-Response Relationship, Drug ; Erythrocytes - immunology ; Histamine Release - drug effects ; Immunity - drug effects ; Immunization ; Immunoglobulin G - analysis ; Immunoglobulin M - analysis ; In Vitro Techniques ; Ketotifen - pharmacology ; Lymphocyte Activation - drug effects ; Male ; Mice ; Mice, Inbred CBA ; Rats ; Rats, Inbred Strains</subject><ispartof>Agents and Actions, 1986-04, Vol.18 (1-2), p.92-95</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-3d3756661fd74d9fe3fd053522b405f4dbc4fb852e419725007adf3a647e1c3f3</citedby><cites>FETCH-LOGICAL-c282t-3d3756661fd74d9fe3fd053522b405f4dbc4fb852e419725007adf3a647e1c3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2425601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gushchin, I S</creatorcontrib><creatorcontrib>Zebrev, A I</creatorcontrib><title>Ketotifen-induced histamine release, inhibition of histamine secretion and modulation of immune response</title><title>Agents and Actions</title><addtitle>Agents Actions</addtitle><description>In concentrations above 0.1 mM Ketotifen (KT) induced secretion of histamine from rat and mouse mast cells, but not from human basophils. 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KT stimulated both IgM- and IgG-immune response to SRBC.</description><subject>Animals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Erythrocytes - immunology</subject><subject>Histamine Release - drug effects</subject><subject>Immunity - drug effects</subject><subject>Immunization</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><subject>In Vitro Techniques</subject><subject>Ketotifen - pharmacology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0065-4299</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1LwzAYh4Moc04v3oWePIjVfKc56nAqDrwoeCtp84ZF2mQ27cH_3rrNj9MLLw8P_B6ETgm-Ihir69sFJrpQWtM9NCWc4lzj4m0fTTGWIudU60N0lNI7xkKQgkzQhHIqJCZTtHqCPvbeQch9sEMNNlv51JvWB8g6aMAkuMx8WPnK9z6GLLp_QIK6g83bBJu10Q6N-aF82w4bR1rHkOAYHTjTJDjZ3Rl6Xdy9zB_y5fP94_xmmde0oH3OLFNCSkmcVdxqB8xZLJigtOJYOG6rmruqEBQ40YqKcb6xjhnJFZCaOTZD51vvuosfA6S-bH2qoWlMgDikUknNiKZiBC-2YN3FlDpw5brzrek-S4LL76zlX9YRPttZh6oF-4vuOrIvtm5zsA</recordid><startdate>198604</startdate><enddate>198604</enddate><creator>Gushchin, I S</creator><creator>Zebrev, A I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198604</creationdate><title>Ketotifen-induced histamine release, inhibition of histamine secretion and modulation of immune response</title><author>Gushchin, I S ; Zebrev, A I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-3d3756661fd74d9fe3fd053522b405f4dbc4fb852e419725007adf3a647e1c3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Dose-Response Relationship, Drug</topic><topic>Erythrocytes - immunology</topic><topic>Histamine Release - drug effects</topic><topic>Immunity - drug effects</topic><topic>Immunization</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><topic>In Vitro Techniques</topic><topic>Ketotifen - pharmacology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gushchin, I S</creatorcontrib><creatorcontrib>Zebrev, A I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Agents and Actions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gushchin, I S</au><au>Zebrev, A I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ketotifen-induced histamine release, inhibition of histamine secretion and modulation of immune response</atitle><jtitle>Agents and Actions</jtitle><addtitle>Agents Actions</addtitle><date>1986-04</date><risdate>1986</risdate><volume>18</volume><issue>1-2</issue><spage>92</spage><epage>95</epage><pages>92-95</pages><issn>0065-4299</issn><eissn>1420-908X</eissn><abstract>In concentrations above 0.1 mM Ketotifen (KT) induced secretion of histamine from rat and mouse mast cells, but not from human basophils. 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| ispartof | Agents and Actions, 1986-04, Vol.18 (1-2), p.92-95 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Dose-Response Relationship, Drug Erythrocytes - immunology Histamine Release - drug effects Immunity - drug effects Immunization Immunoglobulin G - analysis Immunoglobulin M - analysis In Vitro Techniques Ketotifen - pharmacology Lymphocyte Activation - drug effects Male Mice Mice, Inbred CBA Rats Rats, Inbred Strains |
| title | Ketotifen-induced histamine release, inhibition of histamine secretion and modulation of immune response |
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