Hepatoprotective effects of lobenzarit disodium on acetaminophen-induced liver damage in mice
We have studied the effects of the immunomodulator drug lobenzarit in the model of acute hepatotoxicity induced by a high oral dose (600 mg/kg) of acetaminophen in mice. Lobenzarit at doses of 25, 50 and 100 mg/kg i.p. decreased significantly the activity of alanine aminotransferase in serum, which...
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| Veröffentlicht in: | Agents and Actions 1992-09, Vol.37 (1-2), p.114-120 |
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| creator | González, R Pascual, C Ancheta, O Carreras, B Remírez, D Pellón, R |
| description | We have studied the effects of the immunomodulator drug lobenzarit in the model of acute hepatotoxicity induced by a high oral dose (600 mg/kg) of acetaminophen in mice. Lobenzarit at doses of 25, 50 and 100 mg/kg i.p. decreased significantly the activity of alanine aminotransferase in serum, which was increased by acetaminophen alone, and increased the concentration of reduced glutathione in mice liver, which is depleted by acetaminophen. Lobenzarit also reduced liver damage induced by acetaminophen in mice, which was observed by electron microscopy. The hepatoprotective effects of lobenzarit were dose-dependent and they were produced when lobenzarit was administered 30 min before acetaminophen or 2 and 4 h after it. It is concluded that lobenzarit exerts some effects which resemble those of an antidote of acetaminophen such as N-acetylcysteine. |
| doi_str_mv | 10.1007/BF01987899 |
| format | Article |
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Lobenzarit at doses of 25, 50 and 100 mg/kg i.p. decreased significantly the activity of alanine aminotransferase in serum, which was increased by acetaminophen alone, and increased the concentration of reduced glutathione in mice liver, which is depleted by acetaminophen. Lobenzarit also reduced liver damage induced by acetaminophen in mice, which was observed by electron microscopy. The hepatoprotective effects of lobenzarit were dose-dependent and they were produced when lobenzarit was administered 30 min before acetaminophen or 2 and 4 h after it. 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Lobenzarit at doses of 25, 50 and 100 mg/kg i.p. decreased significantly the activity of alanine aminotransferase in serum, which was increased by acetaminophen alone, and increased the concentration of reduced glutathione in mice liver, which is depleted by acetaminophen. Lobenzarit also reduced liver damage induced by acetaminophen in mice, which was observed by electron microscopy. The hepatoprotective effects of lobenzarit were dose-dependent and they were produced when lobenzarit was administered 30 min before acetaminophen or 2 and 4 h after it. It is concluded that lobenzarit exerts some effects which resemble those of an antidote of acetaminophen such as N-acetylcysteine.</description><subject>Acetaminophen - antagonists & inhibitors</subject><subject>Acetaminophen - toxicity</subject><subject>Alanine Transaminase - blood</subject><subject>Alanine Transaminase - drug effects</subject><subject>Animals</subject><subject>Chemical and Drug Induced Liver Injury</subject><subject>Dose-Response Relationship, Drug</subject><subject>Glutathione - metabolism</subject><subject>Liver Diseases - metabolism</subject><subject>Liver Diseases - pathology</subject><subject>Liver Diseases - prevention & control</subject><subject>Male</subject><subject>Mice</subject><subject>Microscopy, Electron</subject><subject>ortho-Aminobenzoates - pharmacology</subject><subject>Oxidation-Reduction - drug effects</subject><issn>0065-4299</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAUhYMo4_jYuBeyciFUb5ImTZY6-ALBjYIbKUl6o5G2GZtW0F9vZQRX9y6-c-B8hBwxOGMA1fnlNTCjK23MFlmykkNhQD9vkyWAkkXJjdklezm_A0jJNFuQBSulYhVfkpdbXNsxrYc0oh_jJ1IMYf4yTYG2yWH_bYc40ibm1MSpo6mn1uNou9in9Rv2ReybyWND2zk80MZ29hVp7GkXPR6QnWDbjId_d588XV89rm6L-4ebu9XFfeEFE2OhpDNeS1aJknMdTBMYOKmMCODAqQq1w-AU843nyoLmch4pXaVAOC0AxD452fTOOz4mzGPdxeyxbW2Paco1UyXjUvAZPN2Afkg5Dxjq9RA7O3zVDOpfl_W_yxk-_mudXIfNP7qRJ34ApA1uxg</recordid><startdate>19920901</startdate><enddate>19920901</enddate><creator>González, R</creator><creator>Pascual, C</creator><creator>Ancheta, O</creator><creator>Carreras, B</creator><creator>Remírez, D</creator><creator>Pellón, R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19920901</creationdate><title>Hepatoprotective effects of lobenzarit disodium on acetaminophen-induced liver damage in mice</title><author>González, R ; Pascual, C ; Ancheta, O ; Carreras, B ; Remírez, D ; Pellón, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-65b9c851734228f9df10b5693f0b0b67e8befb61cdc26a08251425b7603b83003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acetaminophen - antagonists & inhibitors</topic><topic>Acetaminophen - toxicity</topic><topic>Alanine Transaminase - blood</topic><topic>Alanine Transaminase - drug effects</topic><topic>Animals</topic><topic>Chemical and Drug Induced Liver Injury</topic><topic>Dose-Response Relationship, Drug</topic><topic>Glutathione - metabolism</topic><topic>Liver Diseases - metabolism</topic><topic>Liver Diseases - pathology</topic><topic>Liver Diseases - prevention & control</topic><topic>Male</topic><topic>Mice</topic><topic>Microscopy, Electron</topic><topic>ortho-Aminobenzoates - pharmacology</topic><topic>Oxidation-Reduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González, R</creatorcontrib><creatorcontrib>Pascual, C</creatorcontrib><creatorcontrib>Ancheta, O</creatorcontrib><creatorcontrib>Carreras, B</creatorcontrib><creatorcontrib>Remírez, D</creatorcontrib><creatorcontrib>Pellón, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Agents and Actions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González, R</au><au>Pascual, C</au><au>Ancheta, O</au><au>Carreras, B</au><au>Remírez, D</au><au>Pellón, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatoprotective effects of lobenzarit disodium on acetaminophen-induced liver damage in mice</atitle><jtitle>Agents and Actions</jtitle><addtitle>Agents Actions</addtitle><date>1992-09-01</date><risdate>1992</risdate><volume>37</volume><issue>1-2</issue><spage>114</spage><epage>120</epage><pages>114-120</pages><issn>0065-4299</issn><eissn>1420-908X</eissn><abstract>We have studied the effects of the immunomodulator drug lobenzarit in the model of acute hepatotoxicity induced by a high oral dose (600 mg/kg) of acetaminophen in mice. 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| ispartof | Agents and Actions, 1992-09, Vol.37 (1-2), p.114-120 |
| issn | 0065-4299 1420-908X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acetaminophen - antagonists & inhibitors Acetaminophen - toxicity Alanine Transaminase - blood Alanine Transaminase - drug effects Animals Chemical and Drug Induced Liver Injury Dose-Response Relationship, Drug Glutathione - metabolism Liver Diseases - metabolism Liver Diseases - pathology Liver Diseases - prevention & control Male Mice Microscopy, Electron ortho-Aminobenzoates - pharmacology Oxidation-Reduction - drug effects |
| title | Hepatoprotective effects of lobenzarit disodium on acetaminophen-induced liver damage in mice |
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