Anti-inflammatory and antipyretic effects of boldine

Boldine, an antioxidant alkaloid isolated from Peumus boldus, exhibits a dose-dependent anti-inflammatory activity in the carrageenan-induced guinea pig paw edema test with an oral ED50 of 34 mg/kg. Boldine also reduces bacterial pyrogen-induced hyperthermia in rabbits to an extent which varied betw...

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Veröffentlicht in:	Agents and Actions 1994-10, Vol.42 (3-4), p.114-117
Hauptverfasser:	Backhouse, N, Delporte, C, Givernau, M, Cassels, B K, Valenzuela, A, Speisky, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aporphines - pharmacology Carrageenan Chromatography, Thin Layer Dose-Response Relationship, Drug Edema - chemically induced Edema - prevention & control Epoprostenol - biosynthesis Female Fever - chemically induced Fever - pathology Guinea Pigs Lipopolysaccharides - pharmacology Male Rabbits
Online-Zugang:	Volltext
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